Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of SICU, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Oxid Med Cell Longev. 2018 Mar 18;2018:1912746. doi: 10.1155/2018/1912746. eCollection 2018.
Methane, the simplest organic compound, was deemed to have little physiological action for decades. However, recently, many basic studies have discovered that methane has several important biological effects that can protect cells and organs from inflammation, oxidant, and apoptosis. Heretofore, there are two delivery methods that have been applied to researches and have been proved to be feasible, including the inhalation of methane gas and injection with the methane-rich saline. This review studies on the clinical development of methane and discusses about the mechanism behind these protective effects. As a new field in gas medicine, this study also comes up with some problems and prospects on methane and further studies.
甲烷，最简单的有机化合物，数十年来被认为对生理作用影响甚微。然而，最近，许多基础研究发现甲烷具有几种重要的生物学效应，可以保护细胞和器官免受炎症、氧化应激和细胞凋亡的影响。迄今为止，已经有两种输送方法被应用于研究，并已被证明是可行的，包括吸入甲烷气体和注射富甲烷盐水。这篇综述研究了甲烷的临床发展，并讨论了这些保护作用背后的机制。作为气体医学的一个新领域，本研究还提出了一些关于甲烷和进一步研究的问题和展望。
