甲烷治疗作用及其在疾病治疗中的机制。
Therapeutic effect of methane and its mechanism in disease treatment.
机构信息
Department of Aviation and Diving Medicine, the Sixth Medical Center, General Hospital of People's Liberation Army, Beijing 100048, China.
Department of Navy Aviation Medicine, Faculty of Naval Medicine, the Naval Military Medical University, Shanghai 200433, China.
出版信息
J Zhejiang Univ Sci B. 2020;21(8):593-602. doi: 10.1631/jzus.B1900629.
Abstract
Methane is the simplest hydrocarbon, consisting of one carbon atom and four hydrogen atoms. It is abundant in marsh gas, livestock rumination, and combustible ice. Little is known about the use of methane in human disease treatment. Current research indicates that methane is useful for treating several diseases including ischemia and reperfusion injury, and inflammatory diseases. The mechanisms underlying the protective effects of methane appear primarily to involve anti-oxidation, anti-inflammation, and anti-apoptosis. In this review, we describe the beneficial effects of methane on different diseases, summarize possible mechanisms by which methane may act in these conditions, and discuss the purpose of methane production in hypoxic conditions. Then we propose several promising directions for the future research.
摘要
甲烷是最简单的烃类，由一个碳原子和四个氢原子组成。它存在于沼气、牲畜反刍和可燃冰中。目前人们对甲烷在人类疾病治疗中的应用知之甚少。目前的研究表明，甲烷对几种疾病有治疗作用，包括缺血再灌注损伤和炎症性疾病。甲烷发挥保护作用的机制主要涉及抗氧化、抗炎和抗细胞凋亡。在这篇综述中，我们描述了甲烷对不同疾病的有益作用，总结了甲烷在这些情况下可能发挥作用的机制，并讨论了在缺氧条件下产生甲烷的目的。然后，我们提出了未来研究的几个有前途的方向。
相似文献
1
Therapeutic effect of methane and its mechanism in disease treatment.甲烷治疗作用及其在疾病治疗中的机制。
J Zhejiang Univ Sci B. 2020;21(8):593-602. doi: 10.1631/jzus.B1900629.
2
Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation.甲烷改善大鼠脊髓缺血再灌注损伤：由Nrf2激活介导的抗氧化、抗炎和抗凋亡活性。
Free Radic Biol Med. 2017 Feb;103:69-86. doi: 10.1016/j.freeradbiomed.2016.12.014. Epub 2016 Dec 20.
3
Methane attenuates lung ischemia-reperfusion injury via regulating PI3K-AKT-NFκB signaling pathway.甲烷通过调节 PI3K-AKT-NFκB 信号通路减轻肺缺血再灌注损伤。
J Recept Signal Transduct Res. 2020 Jun;40(3):209-217. doi: 10.1080/10799893.2020.1727925. Epub 2020 Feb 21.
4
Protective Effects of Methane-Rich Saline on Renal Ischemic-Reperfusion Injury in a Mouse Model.富甲烷生理盐水对小鼠肾缺血再灌注损伤的保护作用。
Med Sci Monit. 2018 Oct 31;24:7794-7801. doi: 10.12659/MSM.911156.
5
Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties.甲烷医学：一种冉冉升起的明星气体，具有强大的抗炎、抗氧化和抗细胞凋亡特性。
Oxid Med Cell Longev. 2018 Mar 18;2018:1912746. doi: 10.1155/2018/1912746. eCollection 2018.
6
Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.甲烷通过抗氧化、抗凋亡和抗炎作用减轻大鼠心肌缺血损伤。
Free Radic Biol Med. 2016 Jan;90:1-11. doi: 10.1016/j.freeradbiomed.2015.11.017. Epub 2015 Nov 14.
7
The anti-inflammatory effects of methane.甲烷的抗炎作用。
Crit Care Med. 2012 Apr;40(4):1269-78. doi: 10.1097/CCM.0b013e31823dae05.
8
Methane Attenuates Hepatic Ischemia/Reperfusion Injury in Rats Through Antiapoptotic, Anti-Inflammatory, and Antioxidative Actions.甲烷通过抗凋亡、抗炎和抗氧化作用减轻大鼠肝脏缺血/再灌注损伤。
Shock. 2015 Aug;44(2):181-7. doi: 10.1097/SHK.0000000000000385.
9
Inhaled Methane Limits the Mitochondrial Electron Transport Chain Dysfunction during Experimental Liver Ischemia-Reperfusion Injury.吸入甲烷可限制实验性肝缺血再灌注损伤期间的线粒体电子传递链功能障碍。
PLoS One. 2016 Jan 7;11(1):e0146363. doi: 10.1371/journal.pone.0146363. eCollection 2016.
10
Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved.吸入甲烷可保护大鼠免受脑缺血再灌注损伤引起的神经功能障碍：涉及 PI3K/Akt/HO-1 通路。
Arch Med Res. 2017 Aug;48(6):520-525. doi: 10.1016/j.arcmed.2018.01.001.
引用本文的文献
1
Protective role of methane in traumatic nervous system diseases.甲烷在创伤性神经系统疾病中的保护作用。
Med Gas Res. 2024 Sep 1;14(3):159-162. doi: 10.4103/mgr.mgr_23_23. Epub 2024 Mar 20.
2
Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease.肠道微生物群产生的低分子量化合物与心血管疾病。
Int J Mol Sci. 2024 Sep 27;25(19):10397. doi: 10.3390/ijms251910397.
3
Methane saline suppresses ferroptosis via the Nrf2/HO-1 signaling pathway to ameliorate intestinal ischemia-reperfusion injury.甲烷盐水通过 Nrf2/HO-1 信号通路抑制铁死亡，从而改善肠缺血再灌注损伤。
Redox Rep. 2024 Dec;29(1):2373657. doi: 10.1080/13510002.2024.2373657. Epub 2024 Jul 18.
4
A narrative review of methane in treating neurological diseases.甲烷治疗神经疾病的综述。
Med Gas Res. 2023 Oct-Dec;13(4):161-164. doi: 10.4103/2045-9912.372663.
5
aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress.水提物通过抑制炎症和氧化应激改善溃疡性结肠炎小鼠的结肠黏膜损伤和调节肠道微生物失调。
J Zhejiang Univ Sci B. 2022 Jun 15;23(6):481-501. doi: 10.1631/jzus.B2100988.
6
..
J Zhejiang Univ Sci B. 2021 Nov 15;22(11):929-940. doi: 10.1631/jzus.B2000583.
本文引用的文献
1
Methane Production and Bioactivity-A Link to Oxido-Reductive Stress.甲烷生成与生物活性——与氧化还原应激的联系
Front Physiol. 2019 Sep 27;10:1244. doi: 10.3389/fphys.2019.01244. eCollection 2019.
2
Protective effects of methane-rich saline on mice with allergic asthma by inhibiting inflammatory response, oxidative stress and apoptosis.富甲烷盐水通过抑制炎症反应、氧化应激和细胞凋亡对过敏性哮喘小鼠的保护作用。
J Zhejiang Univ Sci B. 2019;20(10):828-837. doi: 10.1631/jzus.B1900195.
3
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-B/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.富甲烷盐水通过阻断 TLR4/NF-B/MAPK 通路和促进 IL-10/JAK1/STAT3 介导的抗炎反应对乙酸诱导的溃疡性结肠炎的保护作用。
Oxid Med Cell Longev. 2019 Apr 28;2019:7850324. doi: 10.1155/2019/7850324. eCollection 2019.
4
Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice.甲烷通过抑制小胶质细胞 NF-κB/MAPKs 通路和促进老年小鼠 IL-10 表达来改善术后认知功能障碍。
Int Immunopharmacol. 2019 Jun;71:52-60. doi: 10.1016/j.intimp.2019.03.003. Epub 2019 Mar 13.
5
Methanogens as emerging pathogens in anaerobic abscesses.产甲烷菌作为厌氧性脓肿中的新兴病原体。
Eur J Clin Microbiol Infect Dis. 2019 May;38(5):811-818. doi: 10.1007/s10096-019-03510-5. Epub 2019 Feb 22.
6
Methane alleviates sepsis-induced injury by inhibiting pyroptosis and apoptosis: in vivo and in vitro experiments.甲烷通过抑制细胞焦亡和凋亡减轻脓毒症诱导的损伤：体内和体外实验
Aging (Albany NY). 2019 Feb 18;11(4):1226-1239. doi: 10.18632/aging.101831.
7
Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress.富含甲烷的盐水通过调节内质网应激，通过抗炎、抗氧化和抗细胞凋亡作用改善脓毒症诱导的急性肾损伤。
Oxid Med Cell Longev. 2018 Nov 15;2018:4756846. doi: 10.1155/2018/4756846. eCollection 2018.
8
Protective Effects of Methane-Rich Saline on Renal Ischemic-Reperfusion Injury in a Mouse Model.富甲烷生理盐水对小鼠肾缺血再灌注损伤的保护作用。
Med Sci Monit. 2018 Oct 31;24:7794-7801. doi: 10.12659/MSM.911156.
9
Methanogenesis.产甲烷作用。
Curr Biol. 2018 Jul 9;28(13):R727-R732. doi: 10.1016/j.cub.2018.05.021.
10
Reduction of nitrosative stress by methane: Neuroprotection through xanthine oxidoreductase inhibition in a rat model of mesenteric ischemia-reperfusion.甲烷减轻氧化应激：黄嘌呤氧化酶抑制在大鼠肠系膜缺血再灌注模型中的神经保护作用。
Free Radic Biol Med. 2018 May 20;120:160-169. doi: 10.1016/j.freeradbiomed.2018.03.024. Epub 2018 Mar 14.
Zotero 插件