外部应力对可生物降解骨科材料的影响：综述

Li Xuan, Chu Chenglin, Chu Paul K

School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.

Jiangsu Key Laboratory for Advanced Metallic Materials, Southeast University, Nanjing, 211189, China.

Bioact Mater. 2016 Sep 13;1(1):77-84. doi: 10.1016/j.bioactmat.2016.09.002. eCollection 2016 Sep.

Biodegradable orthopedic materials (BOMs) are used in rehabilitation and reconstruction of fractured tissues. The response of BOMs to the combined action of physiological stress and corrosion is an important issue since stress-assisted degradation and cracking are common. Although the degradation behavior and kinetics of BOMs have been investigated under static conditions, stress effects can be very serious and even fatal in the dynamic physiological environment. Since stress is unavoidable in biomedical applications of BOMs, recent work has focused on the evaluation and prediction of the properties of BOMs under stress in corrosive media. This article reviews recent progress in this important area focusing on biodegradable metals, polymers, and ceramics.

可生物降解的骨科材料（BOMs）用于骨折组织的修复和重建。由于应力辅助降解和开裂很常见，BOMs对生理应力和腐蚀联合作用的响应是一个重要问题。尽管已在静态条件下研究了BOMs的降解行为和动力学，但在动态生理环境中，应力影响可能非常严重甚至致命。由于在BOMs的生物医学应用中应力不可避免，最近的工作集中在评估和预测BOMs在腐蚀性介质中承受应力时的性能。本文综述了这一重要领域的最新进展，重点关注可生物降解金属、聚合物和陶瓷。