• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.前体蛋白进入线粒体的导入途径：多个受体位点之后是一个共同的膜插入位点。
J Cell Biol. 1988 Dec;107(6 Pt 2):2483-90. doi: 10.1083/jcb.107.6.2483.
2
MOM19, an import receptor for mitochondrial precursor proteins.MOM19，一种线粒体前体蛋白的输入受体。
Cell. 1989 Dec 22;59(6):1061-70. doi: 10.1016/0092-8674(89)90762-9.
3
High-affinity binding sites involved in the import of porin into mitochondria.参与孔蛋白导入线粒体过程的高亲和力结合位点。
EMBO J. 1987 Sep;6(9):2635-42. doi: 10.1002/j.1460-2075.1987.tb02554.x.
4
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex.线粒体外膜孔蛋白的生物合成涉及一条通过受体和TOM复合体的一般导入孔的导入途径。
J Cell Biol. 2001 Jan 22;152(2):289-300. doi: 10.1083/jcb.152.2.289.
5
Proteinaceous receptors for the import of mitochondrial precursor proteins.用于导入线粒体前体蛋白的蛋白质受体。
J Biol Chem. 1984 Jun 25;259(12):7850-6.
6
Biosynthesis of mitochondrial porin and insertion into the outer mitochondrial membrane of Neurospora crassa.粗糙脉孢菌线粒体孔蛋白的生物合成及其插入线粒体外膜的过程
Eur J Biochem. 1982 Aug;126(1):197-202. doi: 10.1111/j.1432-1033.1982.tb06766.x.
7
Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space.
FEBS Lett. 1991 Nov 18;293(1-2):85-8. doi: 10.1016/0014-5793(91)81157-4.
8
Biogenesis of mitochondrial porin: the import pathway.
Experientia. 1990 Feb 15;46(2):153-61. doi: 10.1007/BF02027311.
9
Integration of porin into the outer mitochondrial membrane through the common import machinery located in contact sites.孔蛋白通过位于接触位点的共同导入机制整合到线粒体外膜中。
Biochem Mol Biol Int. 1993 Mar;29(3):429-34.
10
The mitochondrial import machinery for preproteins.前体蛋白的线粒体导入机制。
Crit Rev Biochem Mol Biol. 2001;36(3):291-336. doi: 10.1080/20014091074200.

引用本文的文献

1
The selectivity filter of the mitochondrial protein import machinery.线粒体蛋白输入机制的选择性过滤器。
BMC Biol. 2020 Oct 29;18(1):156. doi: 10.1186/s12915-020-00888-z.
2
The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.Tob55的N端结构域在线粒体β-桶状蛋白的生物合成中具有类似受体的功能。
J Cell Biol. 2007 Jan 1;176(1):77-88. doi: 10.1083/jcb.200602050. Epub 2006 Dec 26.
3
Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins.寻找合适的细胞器。线粒体外膜蛋白中的靶向信号。
EMBO Rep. 2003 Oct;4(10):948-52. doi: 10.1038/sj.embor.embor937.
4
Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane.脱辅基细胞色素c穿过线粒体外膜的转位需要TOM复合体。
EMBO J. 2001 Oct 15;20(20):5626-35. doi: 10.1093/emboj/20.20.5626.
5
Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration.蛋白质导入线粒体：进行性神经退行性变的一种新发病机制。
J Inherit Metab Dis. 2001 Apr;24(2):166-80. doi: 10.1023/a:1010314900814.
6
Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex.线粒体外膜孔蛋白的生物合成涉及一条通过受体和TOM复合体的一般导入孔的导入途径。
J Cell Biol. 2001 Jan 22;152(2):289-300. doi: 10.1083/jcb.152.2.289.
7
The TOM core complex: the general protein import pore of the outer membrane of mitochondria.TOM核心复合体：线粒体外膜的通用蛋白质导入通道。
J Cell Biol. 1999 Nov 29;147(5):959-68. doi: 10.1083/jcb.147.5.959.
8
Mitochondrial protein import: modification of sulfhydryl groups of the inner mitochondrial membrane import machinery in Solanum tuberosum inhibits protein import.线粒体蛋白质输入：马铃薯线粒体内膜输入机制中巯基的修饰抑制蛋白质输入。
Plant Mol Biol. 1997 Dec;35(6):809-20. doi: 10.1023/a:1005838028160.
9
The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane.Tim54p-Tim22p复合物介导蛋白质插入线粒体内膜。
J Cell Biol. 1997 Dec 29;139(7):1663-75. doi: 10.1083/jcb.139.7.1663.
10
The human mitochondrial import receptor, hTom20p, prevents a cryptic matrix targeting sequence from gaining access to the protein translocation machinery.人类线粒体输入受体hTom20p可阻止隐蔽的基质靶向序列接近蛋白质转运机制。
J Cell Biol. 1996 Jul;134(2):307-13. doi: 10.1083/jcb.134.2.307.

本文引用的文献

1
Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins.酵母线粒体的外膜能够特异性地结合细胞质中合成的线粒体蛋白前体。
EMBO J. 1983;2(7):1113-8. doi: 10.1002/j.1460-2075.1983.tb01554.x.
2
Processing of pre-ornithine transcarbamylase requires a zinc-dependent protease localized to the mitochondrial matrix.鸟氨酸转氨甲酰酶前体的加工需要一种定位于线粒体基质的锌依赖性蛋白酶。
Biochem Biophys Res Commun. 1982 Mar 15;105(1):1-7. doi: 10.1016/s0006-291x(82)80002-8.
3
A mitochondrial protease that cleaves the precursor of ornithine carbamoyltransferase. Purification and properties.一种裂解鸟氨酸氨甲酰基转移酶前体的线粒体蛋白酶。纯化及特性。
Eur J Biochem. 1982 Mar 1;122(3):641-7.
4
Membrane and cytosolic components affecting transport of the precursor for ornithine carbamyltransferase into mitochondria.影响鸟氨酸氨甲酰基转移酶前体转运至线粒体的膜成分和胞质成分。
J Biol Chem. 1983 Jun 10;258(11):6667-70.
5
A neutral metallo endoprotease involved in the processing of an F1-ATPase subunit precursor in mitochondria.一种参与线粒体中F1-ATP酶亚基前体加工的中性金属内蛋白酶。
J Biol Chem. 1982 Mar 25;257(6):3177-82.
6
Proteinaceous receptors for the import of mitochondrial precursor proteins.用于导入线粒体前体蛋白的蛋白质受体。
J Biol Chem. 1984 Jun 25;259(12):7850-6.
7
Receptor sites involved in posttranslational transport of apocytochrome c into mitochondria: specificity, affinity, and number of sites.参与脱辅基细胞色素c向线粒体进行翻译后转运的受体位点：特异性、亲和力及位点数量
Proc Natl Acad Sci U S A. 1983 Aug;80(16):4963-7. doi: 10.1073/pnas.80.16.4963.
8
Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides.蛋白质导入线粒体。参与线粒体前体多肽切割的基质定位蛋白酶的部分纯化。
J Biol Chem. 1983 Apr 25;258(8):4937-43.
9
Transfer of proteins into mitochondria. Precursor to the ADP/ATP carrier binds to receptor sites on isolated mitochondria.蛋白质向线粒体的转运。ADP/ATP载体的前体与分离的线粒体上的受体位点结合。
J Biol Chem. 1983 Apr 10;258(7):4071-4.
10
Assembly of cytochrome c. Apocytochrome c is bound to specific sites on mitochondria before its conversion to holocytochrome c.细胞色素c的组装。脱辅基细胞色素c在转化为全细胞色素c之前与线粒体上的特定位点结合。
Eur J Biochem. 1981 Dec;121(1):203-12. doi: 10.1111/j.1432-1033.1981.tb06450.x.

前体蛋白进入线粒体的导入途径：多个受体位点之后是一个共同的膜插入位点。

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.

作者信息

Pfaller R, Steger H F, Rassow J, Pfanner N, Neupert W

机构信息

Institut für Physiologische Chemie, Universität München, Federal Republic of Germany.

出版信息

J Cell Biol. 1988 Dec;107(6 Pt 2):2483-90. doi: 10.1083/jcb.107.6.2483.

DOI:10.1083/jcb.107.6.2483
PMID:2974457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2115691/
Abstract

The precursor of porin, a mitochondrial outer membrane protein, competes for the import of precursors destined for the three other mitochondrial compartments, including the Fe/S protein of the bc1-complex (intermembrane space), the ADP/ATP carrier (inner membrane), subunit 9 of the F0-ATPase (inner membrane), and subunit beta of the F1-ATPase (matrix). Competition occurs at the level of a common site at which precursors are inserted into the outer membrane. Protease-sensitive binding sites, which act before the common insertion site, appear to be responsible for the specificity and selectivity of mitochondrial protein uptake. We suggest that distinct receptor proteins on the mitochondrial surface specifically recognize precursor proteins and transfer them to a general insertion protein component (GIP) in the outer membrane. Beyond GIP, the import pathways diverge, either to the outer membrane or to translocation contact-sites, and then subsequently to the other mitochondrial compartments.

摘要

孔蛋白（一种线粒体外膜蛋白）的前体，会竞争其他三种线粒体区室的前体蛋白的导入，包括bc1复合体的铁硫蛋白（膜间隙）、ADP/ATP载体（内膜）、F0 - ATP酶的亚基9（内膜）以及F1 - ATP酶的β亚基（基质）。竞争发生在将前体插入外膜的共同位点水平。在共同插入位点之前起作用的蛋白酶敏感结合位点，似乎负责线粒体蛋白摄取的特异性和选择性。我们认为，线粒体表面不同的受体蛋白特异性识别前体蛋白，并将它们转移到外膜中的一般插入蛋白组分（GIP）。除了GIP之外，导入途径会发生分歧，要么进入外膜，要么进入转位接触位点，然后随后进入其他线粒体区室。