寻找合适的细胞器。线粒体外膜蛋白中的靶向信号。
Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins.
作者信息
Rapaport Doron
机构信息
Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, D-81377 Munich, Germany.
出版信息
EMBO Rep. 2003 Oct;4(10):948-52. doi: 10.1038/sj.embor.embor937.
Abstract
The mitochondrial outer membrane contains a diverse set of proteins that includes enzymes, components of the preprotein translocation machinery, pore-forming proteins, regulators of programmed cell death, and those that control the morphology of the organelle. All these proteins, like the vast majority of mitochondrial proteins, are encoded in the nucleus, so they are synthesized in the cytosol and contain signals that are essential for their subsequent import into mitochondria. This review summarizes our current knowledge of the signals that target mitochondrial outer-membrane proteins to their correct intracellular location. In addition, the mechanisms by which these signals are decoded by the mitochondria are discussed.
摘要
线粒体外膜包含多种蛋白质，其中包括酶、前体蛋白转运机制的组分、成孔蛋白、程序性细胞死亡的调节因子以及那些控制细胞器形态的蛋白。所有这些蛋白质，与绝大多数线粒体蛋白质一样，都是由细胞核编码的，因此它们在细胞质中合成，并含有对其随后导入线粒体至关重要的信号。本综述总结了我们目前对将线粒体外膜蛋白靶向到其正确细胞内位置的信号的认识。此外，还讨论了线粒体对这些信号进行解码的机制。
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