CoLaus Study (BU19_02 627), Department of Medicine, Internal Medicine, Lausanne University Hospital, Rue du Bugnon 19, 1011, Lausanne, Switzerland.
Research Group Longitudinal and Intervention Research, Department of Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Eur J Appl Physiol. 2018 Jul;118(7):1507-1514. doi: 10.1007/s00421-018-3881-4. Epub 2018 May 9.
Physical activity (PA) has been shown to influence salivary cortisol concentrations in small studies conducted among athletes. We assessed the association of activity status and patterns with salivary cortisol in the general population.
Cross-sectional study including 1948 adults (54.9% women, 45-86 years). PA and sedentary behaviour (SB) were measured for 14 days by accelerometry. Low PA and high SB status were defined, respectively, as the lowest and highest tertile of each behaviour. 'Inactive', 'Weekend warrior', and 'Regularly active' patterns were also defined. Four salivary cortisol samples were collected over a single day and the following parameters were calculated: area under the curve to ground (AUCg), awakening response (CAR) and diurnal slope.
After multivariable adjustment, low SB remained associated to steeper slopes relative to high SB (- 1.54 ± 0.03 vs. - 1.44 ± 0.04 nmol/l per hour). Non-significant trends were found for high PA relative to low PA with steeper slopes (- 1.54 ± 0.03 vs. - 1.45 ± 0.04) and lower AUCg (208.7 ± 2.0 vs. 215.9 ± 2.9 nmol.h/l). Relative to 'Inactives', 'Regularly actives' had lower AUCg (205.4 ± 2.4 vs. 215.5 ± 2.9) and 'Weekend warriors' had steeper slopes (- 1.61 ± 0.05 vs. - 1.44 ± 0.04). No associations were found for CAR.
Low SB and high PA are related to lower cortisol secretion as measured by different parameters of salivary cortisol, but the effects were only modest.
已有小型研究表明，体力活动（PA）会影响唾液皮质醇浓度。我们评估了在普通人群中，活动状态和模式与唾液皮质醇的相关性。
横断面研究纳入了 1948 名成年人（女性占 54.9%，年龄 45-86 岁）。通过加速度计测量 14 天的 PA 和久坐行为（SB）。低 PA 和高 SB 状态分别定义为两种行为的最低和最高三分位。还定义了“不活动”、“周末战士”和“经常活动”模式。在一天内采集 4 份唾液皮质醇样本，计算以下参数：基础下面积（AUCg）、觉醒反应（CAR）和日间斜率。
在多变量调整后，与高 SB 相比，低 SB 仍与更陡峭的斜率相关（-1.54±0.03 比 -1.44±0.04 nmol/l per hour）。与低 PA 相比，高 PA 与更陡峭的斜率（-1.54±0.03 比 -1.45±0.04）和更低的 AUCg（208.7±2.0 比 215.9±2.9 nmol.h/l）呈无显著趋势。与“不活动”相比，“经常活动”的 AUCg 更低（205.4±2.4 比 215.5±2.9），“周末战士”的斜率更陡（-1.61±0.05 比 -1.44±0.04）。未发现 CAR 有相关性。
低 SB 和高 PA 与唾液皮质醇不同参数测量的皮质醇分泌减少有关，但影响较小。
