Sousa Ana Carolina Patrício de Albuquerque, Marchand Alain, Garcia Angeles, Gomez Jose Fernando, Ylli Alban, Guralnik Jack M, Zunzunegui Maria-Victoria, Guerra Ricardo Oliveira
CNPQ Programa de Pós Graduação em Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Institut de recherche en santé publique de l'Université de Montréal (IRSPUM), Montreal, Canada.
Arch Gerontol Geriatr. 2017 Jul;71:50-58. doi: 10.1016/j.archger.2017.03.002. Epub 2017 Mar 9.
To compare diurnal cortisol profiles across samples of older adults from diverse populations and to examine if differences in circadian cortisol secretion are associated with poor physical performance (SPPB<9).
Data were collected during the baseline survey of the International Mobility in Aging Study conducted in 2012 in Kingston (Canada), Saint-Hyacinthe (Canada), Tirana (Albania) and Manizales (Colombia). Salivary cortisol was collected from a subsample of 309 participants instructed to collect saliva on two consecutive days, and 5 different intervals each day: upon awakening (M1), 30min (M2) and 60min after awakening, at 15:00h and before bedtime (E). Cortisol was analyzed using enzyme immunoassay kits. Physical performance was measured by the Short Physical Performance Battery (SPPB). Mixed linear models were fit to assess the associations between cortisol diurnal output and physical performance, adjusting for potential confounders.
Kingston, Saint-Hyacinthe and Tirana residents had significantly higher cortisol values than their Manizales counterparts, with the population from Tirana showing the highest levels. Attenuated morning cortisol peak (M2) (p=0.025), higher cortisol bed time (E) (p=0.005), and lower M2/E ratio (p<0.001) were found among those with SPPB<9 compared with those with good physical performance (SPPB≥9). These results were not altered after adjustment by potential confounders.
Cortisol profiles varied across four diverse populations of older adults. Circadian cortisol secretion is associated with physical performance as an attenuated morning response and higher bed time values were observed in older adults with SPPB<9.
比较不同人群中老年人样本的昼夜皮质醇水平，并研究昼夜皮质醇分泌差异是否与身体机能差（短身体机能测试量表得分<9分）相关。
数据收集于2012年在加拿大金斯敦、加拿大圣亚森特、阿尔巴尼亚地拉那和哥伦比亚马尼萨莱斯开展的国际老年流动性研究的基线调查期间。从309名参与者的子样本中收集唾液皮质醇，这些参与者被要求连续两天每天在5个不同时间点收集唾液：醒来时（M1）、醒来后30分钟（M2）、醒来后60分钟、15:00以及就寝前（E）。使用酶免疫分析试剂盒分析皮质醇。通过短身体机能测试量表（SPPB）测量身体机能。采用混合线性模型评估皮质醇昼夜分泌量与身体机能之间的关联，并对潜在混杂因素进行校正。
金斯敦、圣亚森特和地拉那的居民的皮质醇值显著高于马尼萨莱斯的居民，地拉那的人群皮质醇水平最高。与身体机能良好（SPPB≥9）的人相比，SPPB<9的人早晨皮质醇峰值减弱（M2）（p=0.025）、就寝时皮质醇水平较高（E）（p=0.005）以及M2/E比值较低（p<0.001）。在对潜在混杂因素进行校正后，这些结果并未改变。
四个不同老年人群体的皮质醇水平各不相同。昼夜皮质醇分泌与身体机能相关，因为在SPPB<9的老年人中观察到早晨反应减弱和就寝时皮质醇值较高。
