Savage N W, Mahanonda R, Seymour G J, Bryson G J, Collins R J
Department of Oral Biology, University of Queensland, Australia.
J Oral Pathol. 1988 Jul;17(6):293-7. doi: 10.1111/j.1600-0714.1988.tb01539.x.
A flow cytometric analysis of peripheral blood lymphocytes was undertaken in recurrent aphthous stomatitis patients. The project aimed at detecting differences within lymphocyte subsets using type-specific monoclonal antibodies. Peripheral blood samples were taken from RAS patients in both active and remission phases of the disease and from a group of healthy control subjects. There were no statistical differences between the active and remission phases within any of the lymphocyte subsets examined. There was, however, a significant difference between the RAS group and the control group. RAS patients have depressed CD4+ cell numbers and elevated CD8+ cell numbers. The CD4:CD8 ratio is also depressed. A dissection of the CD4+ subset shows raised numbers of CD4+, 4B4+ lymphocytes and depressed numbers of CD4+, 2H4+ lymphocytes. Previous studies have shown disruption of peripheral blood lymphocyte numbers in Behçet's syndrome. A similar pattern has now been shown in uncomplicated cases of minor RAS.
对复发性阿弗他口炎患者的外周血淋巴细胞进行了流式细胞术分析。该项目旨在使用型特异性单克隆抗体检测淋巴细胞亚群之间的差异。从疾病活动期和缓解期的复发性阿弗他口炎患者以及一组健康对照受试者中采集外周血样本。在所检测的任何淋巴细胞亚群中，活动期和缓解期之间均无统计学差异。然而，复发性阿弗他口炎组与对照组之间存在显著差异。复发性阿弗他口炎患者的CD4 +细胞数量减少，CD8 +细胞数量增加。CD4:CD8比率也降低。对CD4 +亚群的剖析显示，CD4 +、4B4 +淋巴细胞数量增加，而CD4 +、2H4 +淋巴细胞数量减少。先前的研究表明白塞病患者外周血淋巴细胞数量紊乱。现在在单纯性轻度复发性阿弗他口炎病例中也显示出类似的模式。
