Lukoseviciene Vaida, Tikuisis Renatas, Dulskas Audrius, Miliauskas Povilas, Ostapenko Valerijus
Radiotherapy Department, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
J BUON. 2018 Mar-Apr;23(2):290-295.
Breast cancer is the most frequently diagnosed cancer in females. Triple negative breast cancer (TNBC) is a molecular subtype of breast cancer which has a high mortality rate because of aggressive proliferation, quick occurrence of metastasis, and lack of effective treatment. New data show evidence that the type of anaesthesia can affect breast cancer recurrence and long-term outcome. Because TNBC lacks targets for modern specific therapy, a perioperative period could be the field of investigations for the long-term outcomes in TNBC influence. We reviewed the literature on research focusing on the influence of anaesthetics to oxidative stress, inflammation, molecular regulators, and TNBC oncological outcomes.
乳腺癌是女性中最常被诊断出的癌症。三阴性乳腺癌（TNBC）是乳腺癌的一种分子亚型，因其侵袭性增殖、快速发生转移且缺乏有效治疗方法，死亡率很高。新数据表明，麻醉类型会影响乳腺癌的复发和长期预后。由于TNBC缺乏现代特异性治疗的靶点，围手术期可能是研究TNBC长期预后影响的领域。我们回顾了关于麻醉对氧化应激、炎症、分子调节因子和TNBC肿瘤学结局影响的研究文献。
