Yusen Wei, Xia Wang, Shengjun Yang, Shaohui Zhou, Hongzhen Zhang
Graduate School of Hebei Medical University, Hebei, P.R.China.
J BUON. 2018 Mar-Apr;23(2):398-402.
The purpose of this investigation was to determine the expression and significance of tumor associated macrophages (TAMs) and CXCR4 in non-small cell lung cancer (NSCLC).
Immunohistochemical staining was used to analyze the expression of CD68 (TAM surface marker) and CXCR4 in 68 cases of NSCLC and 17 cases of normal lung tissue.
The positive rate of CD68 was 66.2% (45/68) and CXCR4 was 61.8% (42/68) in the lung cancer tissues, while the rates in normal tissues were statistically significantly lower at 27.3% (3/17) and 11.8% (2/17), respectively. The tissue expressions of CD68 and CXCR4 in NSCLC tissues were significantly correlated with a higher TNM staging and lymph node metastasis (p<0.05); and the expression of CD68 was positively correlated with the expression of CXCR4 (r=0.461, p=0.000). The TAMs infiltration and the expression of CXCR4 were closely correlated with the cellular carcinogenesis and development of NSCLC and their combined detection could provide a potential target for clinical diagnosis and adjuvant therapy for patient with NSCLC.
本研究旨在确定肿瘤相关巨噬细胞（TAM）和CXCR4在非小细胞肺癌（NSCLC）中的表达及意义。
采用免疫组织化学染色法分析68例NSCLC组织及17例正常肺组织中CD68（TAM表面标志物）和CXCR4的表达。
肺癌组织中CD68阳性率为66.2%（45/68），CXCR4阳性率为61.8%（42/68），而正常组织中的阳性率分别为27.3%（3/17）和11.8%（2/17），差异有统计学意义。NSCLC组织中CD68和CXCR4的组织表达与较高的TNM分期和淋巴结转移显著相关（p<0.05）；CD68表达与CXCR4表达呈正相关（r=0.461，p=0.000）。TAM浸润和CXCR4表达与NSCLC的细胞发生和发展密切相关，联合检测可为NSCLC患者的临床诊断和辅助治疗提供潜在靶点。
