Kopanakis Nikolaos, Argyriou Eleftherios-Orestis, Vassiliadou Dimitra, Sidera Christina, Chionis Maria, Kyriazanos John, Efstathiou Elias, Spiliotis John
1st Department of Surgical Oncology, "Metaxa" Cancer Hospital, Piraeus, Greece.
J BUON. 2018 Mar-Apr;23(2):488-493.
Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has become a crucial method in the management of peritoneal metastasis. This study evaluated the Quality of Life (QoL) post CRS plus HIPEC.
80/95 patients underwent CRS plus HIPEC at the Metaxa Cancer Hospital, Piraeus, Greece from 06/2011 to 06/2015 and completed the colorectal version of the Functional Assessment of Cancer Therapy questionnaire (FACTC, version 4) at 1 week pre-operatively and at 1, 3, 6, 12, 18, 24 months post-operatively. The subscales assessed were the physical, social/family, emotional and functional wellbeing.
In all subscales, fluctuations in the scores indicated a worsening of QoL in the first 3 post-operative months, followed by improvement back to pre-operative levels and even better scores later on. Statistical improvement was proven for the physical and emotional well-being subscales.
The significant improvement in the physical well-being is attributed to the eradication of symptoms, whereas the relevant improvements in the emotional wellbeing subscale are explained both by the pre-operative desperation of the diagnosis or relapse of malignancy, and the post-operative hopefulness after a successful operation.
细胞减灭术（CRS）联合腹腔热灌注化疗（HIPEC）已成为治疗腹膜转移的关键方法。本研究评估了CRS联合HIPEC术后的生活质量（QoL）。
2011年6月至2015年6月期间，80/95例患者在希腊比雷埃夫斯的梅塔卡癌症医院接受了CRS联合HIPEC治疗，并在术前1周以及术后1、3、6、12、18、24个月完成了癌症治疗功能评估问卷（FACTC，第4版）的结直肠版本。评估的子量表包括身体、社会/家庭、情感和功能健康状况。
在所有子量表中，评分波动表明术后前3个月生活质量恶化，随后改善至术前水平，甚至在之后获得更好的评分。身体和情感健康子量表经统计学检验有改善。
身体状况的显著改善归因于症状的消除，而情感健康子量表的相关改善既可以通过术前对恶性肿瘤诊断或复发的绝望，以及术后成功手术带来的希望来解释。
