Miner L K, Cheung C Y, Brace R A
Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093.
Am J Obstet Gynecol. 1988 Dec;159(6):1341-6. doi: 10.1016/0002-9378(88)90553-4.
The present study was designed to test the hypothesis that the fetal autonomic nervous system modulates the fetal plasma atrial natriuretic factor and urine flow responses to vascular volume expansion. To do this, isotonic saline solution (2% of estimated body weight) was infused intravascularly over a 10-minute period into autonomically intact or autonomically blocked fetal sheep. The autonomically intact fetuses responded to the infusion with a significant rise in arterial and venous pressures (p less than 0.0001), and atrial natriuretic factor increased by 36 +/- 8 (SE) pg/ml (p less than 0.05). In the autonomically blocked fetuses, the arterial pressure rise was greater (7.5 +/- 1.3 vs 2.6 +/- 0.7 mm Hg), whereas the venous pressure rise was not different from that seen in the intact fetuses. Atrial natriuretic factor increased by 44 +/- 20 pg/ml (p less than 0.05) in the blocked fetuses. Urine flow increased by similar amounts in the two groups (maximal increase above control of 0.33 +/- 0.11 in the intact and 0.27 +/- 0.10 ml/min in the blocked fetuses). Thus autonomic blockade did not significantly alter either the atrial natriuretic factor, urine flow, or venous pressure responses to volume loading in the fetal sheep. Therefore it appears that the autonomic nervous system does not play a major role in modulating atrial natriuretic factor, urine flow, or venous pressure responses to acute vascular volume expansion in the late gestational fetal sheep.
本研究旨在验证胎儿自主神经系统调节胎儿血浆心钠素以及对血管容量扩张的尿流反应这一假设。为此，在10分钟内将等渗盐溶液（估计体重的2%）血管内输注到自主神经系统完整或自主神经被阻断的胎羊体内。自主神经系统完整的胎儿对输注的反应是动脉压和静脉压显著升高（p<0.0001），心钠素增加36±8（标准误）pg/ml（p<0.05）。在自主神经被阻断的胎儿中，动脉压升高幅度更大（7.5±1.3对2.6±0.7 mmHg），而静脉压升高与完整胎儿无差异。自主神经被阻断的胎儿心钠素增加44±20 pg/ml（p<0.05）。两组尿流增加量相似（完整胎儿最大增加量超过对照0.33±0.11，阻断胎儿为0.27±0.10 ml/min）。因此，自主神经阻断并未显著改变胎羊对容量负荷的心钠素、尿流或静脉压反应。所以，自主神经系统在调节妊娠晚期胎羊对急性血管容量扩张的心钠素、尿流或静脉压反应中似乎并不起主要作用。
