Department of Radiology, E-Da Hospital, No.1, Yida Road, Kaohsiung 824, Taiwan.
Department of Radiology, Kaohsiung Municipal Min-Sheng Hospital, No. 134, Kaisyuan 2nd Rd, Kaohsiung 802, Taiwan.
J Infect. 2018 Sep;77(3):212-219. doi: 10.1016/j.jinf.2018.03.014. Epub 2018 May 7.
To investigate the risk of autoimmune diseases in dengue patients.
We conducted a population-based cohort study by the Taiwan National Health Insurance Research Database, including a total of 12,506 newly diagnosed dengue patients and 112,554 control subjects between 2000 and 2010, matched by gender, age, income, urbanization, and comorbidities. Both cohorts were followed for a 3-year period to examine the incidence of autoimmune diseases. A Cox proportional hazards regression analysis was applied to calculate the risk of autoimmune diseases between both groups.
The dengue group showed an overall increased risk for 21 autoimmune diseases, with an adjusted hazard ratio (aHR) of 1.88 (95% confidence interval [CI], 1.49-2.37, p < 0.001). Compared with the control group, the dengue group had higher risks of Reiter's syndrome (aHR 14.03, 95 % CI 1.63-120.58), multiple sclerosis (aHR 11.57, 95 % CI 1.8-74.4), myasthenia gravis (aHR 5.35, 95 % CI 1.43-20.02), autoimmune encephalomyelitis (aHR 3.8, 95% CI 1.85-7.8), systemic vasculitis (aHR 3.7, 95 % CI 1.11-12.28), systemic lupus erythematosus (aHR 3.5, 95% CI 1.85-6.63), and primary adrenocortical insufficiency (aHR 2.05, 95% CI 1.25-3.35).
Dengue patients were associated with an increased risk of autoimmune diseases.
探讨登革热患者发生自身免疫性疾病的风险。
我们通过台湾全民健康保险研究数据库进行了一项基于人群的队列研究，共纳入了 2000 年至 2010 年间 12506 例新诊断的登革热患者和 112554 例对照，按性别、年龄、收入、城市化程度和合并症进行匹配。对两组患者均进行了 3 年的随访，以观察自身免疫性疾病的发病率。采用 Cox 比例风险回归分析计算两组之间发生自身免疫性疾病的风险比。
登革热组发生 21 种自身免疫性疾病的总体风险增加，调整后的风险比（aHR）为 1.88（95%置信区间[CI]，1.49-2.37，p<0.001）。与对照组相比，登革热组发生赖特尔综合征（aHR 14.03，95%CI 1.63-120.58）、多发性硬化症（aHR 11.57，95%CI 1.8-74.4）、重症肌无力（aHR 5.35，95%CI 1.43-20.02）、自身免疫性脑脊髓炎（aHR 3.8，95%CI 1.85-7.8）、系统性血管炎（aHR 3.7，95%CI 1.11-12.28）、系统性红斑狼疮（aHR 3.5，95%CI 1.85-6.63）和原发性肾上腺皮质功能不全（aHR 2.05，95%CI 1.25-3.35）的风险均增加。
登革热患者发生自身免疫性疾病的风险增加。
