Ebrahimpour Anahita, Vaghari-Tabari Mostafa, Qujeq Durdi, Moein Soheila, Moazezi Zoleikha
Student Research Committee, Babol University of Medical Sciences, Babol, Iran; Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran.
Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Diabetes Metab Syndr. 2018 Nov;12(6):863-867. doi: 10.1016/j.dsx.2018.05.002. Epub 2018 May 5.
Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue.
Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group. Serum insulin, triglyceride, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and homocysteine levels were measured. Obtained data compared between groups with independent sample t-test. For evaluation of the correlation between mentioned parameters Pearson correlation coefficient method was used.
Serum levels of LDL-C and total cholesterol significantly increased in SCH group compared to healthy control group. Homeostatic Model Assessment of Insulin Resistance (HOM-IR) and serum homocysteine level significantly elevated in patients with SCH compared to control group. There was a significant direct correlation between HOM-IR and serum homocysteine levels in SCH patients.
Subclinical hypothyroidism likely have significant effect on insulin resistance as major diabetes risk factors and also cardiovascular disease risk factors such as homocysteine. The direct correlation between HOM-IR with serum homocysteine level indicate the possible role of insulin resistance in elevation of serum homocysteine in SCH patient group.
亚临床甲状腺功能减退是一种无明显体征和症状的轻度甲状腺疾病。亚临床甲状腺功能减退与一些心血管疾病危险因素如血脂、同型半胱氨酸水平以及胰岛素抵抗指数之间的相关性尚未明确，本研究旨在阐明这一问题。
选择74例促甲状腺激素（TSH）水平轻度升高而T3和T4水平正常的患者作为患者组，选择74例年龄和性别匹配的个体作为健康对照组。测定血清胰岛素、甘油三酯、葡萄糖、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和同型半胱氨酸水平。两组间的数据采用独立样本t检验进行比较。为评估上述参数之间的相关性，采用Pearson相关系数法。
与健康对照组相比，亚临床甲状腺功能减退组的血清低密度脂蛋白胆固醇和总胆固醇水平显著升高。与对照组相比，亚临床甲状腺功能减退患者的胰岛素抵抗稳态模型评估（HOM-IR）和血清同型半胱氨酸水平显著升高。亚临床甲状腺功能减退患者的HOM-IR与血清同型半胱氨酸水平之间存在显著的正相关。
亚临床甲状腺功能减退可能对作为主要糖尿病危险因素的胰岛素抵抗以及同型半胱氨酸等心血管疾病危险因素有显著影响。HOM-IR与血清同型半胱氨酸水平之间的正相关表明胰岛素抵抗在亚临床甲状腺功能减退患者组血清同型半胱氨酸升高方面可能发挥的作用。
