Tanaci Nedret, Ertugrul Derun Taner, Sahin Mustafa, Yucel Muammer, Olcay Irem, Demirag Nilgun Guvener, Gursoy Alptekin
Department of Endocrinology and Metabolic Diseases, Baskent University Faculty of Medicine, Turkey.
Endocrine. 2006 Jun;29(3):451-6. doi: 10.1385/ENDO:29:3:451.
Postprandial lipoprotein metabolism is suggested to play a role in the pathogenesis of atherosclerosis. In this study, we investigated postprandial lipemia and its relationship to cardiovascular risk factors in patients with overt and subclinical hypothyroidism. Twenty-nine female patients with TSH levels greater than 5 microIU/mL and 12 euthyroid control female subjects were included in the study. Fifteen patients had subclinical hypothyroidism and 14 had overt hypothyroidism. All subjects underwent an oral lipid tolerance test. If triglyceride levels increased by 80% or more, subjects were considered postprandial lipemia positive. Control, overt hypothyroid, and subclinical hypothyroid groups were not statistically different with respect to anthropometric measurements, fasting blood C-reactive protein, uric acid, homocysteine, glucose, insulin, lipoprotein (a), apolipoprotein B levels, and homeostasis model assessment index. Fasting triglyceride levels correlated positively with TSH levels. Postprandial lipemia frequency was higher in overt hypothyroid subjects than in the control group. The subclinical hypothyroid group did not differ from the hypothyroid group with respect to postprandial lipemia frequency. In subjects with TSH levels higher than 5 microIU/mL, PPL risk was increased sevenfold. The results of this study show that postprandial triglyceride metabolism is affected in hypothyroidism.
餐后脂蛋白代谢被认为在动脉粥样硬化的发病机制中起作用。在本研究中，我们调查了显性和亚临床甲状腺功能减退患者的餐后血脂异常及其与心血管危险因素的关系。29名促甲状腺激素（TSH）水平大于5微国际单位/毫升的女性患者和12名甲状腺功能正常的对照女性受试者纳入研究。15名患者为亚临床甲状腺功能减退，14名患者为显性甲状腺功能减退。所有受试者均接受口服脂质耐量试验。如果甘油三酯水平升高80%或更多，则受试者被认为餐后血脂异常阳性。对照组、显性甲状腺功能减退组和亚临床甲状腺功能减退组在人体测量学指标、空腹血C反应蛋白、尿酸、同型半胱氨酸、血糖、胰岛素、脂蛋白（a）、载脂蛋白B水平以及稳态模型评估指数方面无统计学差异。空腹甘油三酯水平与TSH水平呈正相关。显性甲状腺功能减退受试者的餐后血脂异常频率高于对照组。亚临床甲状腺功能减退组与甲状腺功能减退组在餐后血脂异常频率方面无差异。在TSH水平高于5微国际单位/毫升的受试者中，餐后血脂异常风险增加了7倍。本研究结果表明，甲状腺功能减退会影响餐后甘油三酯代谢。
