三种新型高度含氧的大根香叶烯型倍半萜及其细胞毒性。

Three New Highly Oxygenated Germacranolides from and Their Cytotoxic Activity.

机构信息

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.

出版信息

Molecules. 2018 May 3;23(5):1078. doi: 10.3390/molecules23051078.

DOI:10.3390/molecules23051078

PMID:29751555

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6102670/

Abstract

Three new highly oxygenated (⁻), and two known ( and ) germacranolides, were isolated from the whole plant of . The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds ⁻ were determined using similar CD spectra with . The new compound and the known compound exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control -platin.

摘要

从全草中分离得到 3 种新的高含氧（⁻）倍半萜和 2 种已知（和）倍半萜。通过详细的光谱分析确定了新化合物的平面结构和相对构型。通过圆二色性（CD）法和 X 射线衍射确定了的绝对构型，通过与的相似 CD 光谱确定了新化合物⁻的立体化学。新化合物和已知化合物对肝癌（Hep G2）和人宫颈癌（HeLa）细胞表现出很强的细胞毒性，优于阳性对照顺铂。