Marine College, Shandong University, Weihai 264209, PR China.
Fitoterapia. 2012 Dec;83(8):1351-5. doi: 10.1016/j.fitote.2012.04.016. Epub 2012 Apr 28.
In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.
在从中国药用植物中寻找细胞毒性萜类化合物的过程中，从苍耳全草中分离得到了两种新的倍半萜，5α-羟基-13-甲氧基-7αH,11αH-桉叶-4(15)-烯-12,8β-内酯（1）和 1β-羟基-7αH,11αH-桉叶-4(15)-烯-12,8β-内酯（2），以及 14 种已知的倍半萜。新化合物的结构通过光谱方法确定，包括 IR、HRESIMS 以及 1D 和 2D NMR 光谱。通过 MTT 法评估了选定的倍半萜内酯对人口腔表皮样癌（KB）、人乳腺癌（MCF-7）和人肝癌（HepG-2）细胞的细胞毒性。
