根据亚型、代谢综合征和治疗，体重指数对乳腺癌患者生存的影响。
Effect of Body Mass Index on Survival in Breast Cancer Patients According to Subtype, Metabolic Syndrome, and Treatment.
机构信息
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
出版信息
Clin Breast Cancer. 2018 Oct;18(5):e1141-e1147. doi: 10.1016/j.clbc.2018.04.010. Epub 2018 Apr 19.
PURPOSE
To investigate the effect of body mass index (BMI) on survival in patients with breast cancer according to tumor subtype, metabolic syndrome, and systemic treatment.
PATIENTS AND METHODS
We identified 5668 patients who underwent curative surgery for breast cancer between 1996 and 2013 from the clinical data of a single institution. Disease-free survival (DFS) and overall survival (OS) were calculated and compared between the patients with BMI ≥ 25 kg/m and < 25 kg/m in all patients and in specific subgroups, including tumor subtype, metabolic syndrome, and systemic treatment.
RESULTS
In all patients, BMI ≥ 25 kg/m was an unfavorable factor for OS (P = .030) but not for DFS. In the HR/HER2- subgroup, DFS and OS were longer in patients with BMI < 25 kg/m than ≥ 25 kg/m (P = .012 and .005, respectively). In patients with more than one metabolic syndrome, BMI was an unfavorable factor for OS (hazard ratio, 2.669; P < .001) CONCLUSION: BMI ≥ 25 kg/m was an unfavorable survival factor, particularly in patients with HR/HER2- breast cancer.
目的
根据肿瘤亚型、代谢综合征和全身治疗，研究体重指数（BMI）对乳腺癌患者生存的影响。
患者与方法
我们从单机构的临床数据中确定了 5668 名在 1996 年至 2013 年间接受乳腺癌根治性手术的患者。计算并比较了所有患者以及特定亚组（包括肿瘤亚型、代谢综合征和全身治疗）中 BMI≥25kg/m 和<25kg/m 的患者的无病生存率（DFS）和总生存率（OS）。
结果
在所有患者中，BMI≥25kg/m 是 OS 的不利因素（P=0.030），但不是 DFS。在 HR/HER2-亚组中，BMI<25kg/m 的患者的 DFS 和 OS 长于 BMI≥25kg/m 的患者（P=0.012 和 0.005）。在患有多种代谢综合征的患者中，BMI 是 OS 的不利因素（风险比，2.669；P<.001）。
结论
BMI≥25kg/m 是生存的不利因素，尤其是在 HR/HER2-乳腺癌患者中。
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