Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China,
Oncol Res Treat. 2019;42(4):195-201. doi: 10.1159/000496548. Epub 2019 Mar 8.
The aim of this study was to investigate the association between body mass index (BMI) and prognosis of Chinese women with breast cancer.
3,380 primary breast cancer patients who underwent surgery from 2010 to 2012 were selected and classified as low BMI group (BMI < 25.0) and high BMI group (BMI ≥ 25.0). The follow-up data for disease-free survival (DFS) and overall survival (OS) were obtained from 3,178 patients (median follow-up of 58 months). Cox regression analysis was used to evaluate the effect of BMI on DFS and OS.
The high BMI group showed more aggressive pathological features. BMI was negatively associated with OS (hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.06-1.66; p = 0.012) but not DFS (HR 1.15, 95% CI 0.94-1.40; p = 0.17). Furthermore, when stratified by age, BMI was significantly and negatively associated with OS (HR 1.43, 95% CI 1.05-1.95; p = 0.025) in patients above 50 years of age, but this effect was not detected in younger patients.
BMI was an independent prognostic factor of OS in Chinese women with breast cancer, and age might be a mitigating factor. Among patients above 50 years of age, those with a high BMI were at greater risk of poor prognosis compared to individuals with a low BMI.
本研究旨在探讨体质指数（BMI）与中国女性乳腺癌患者预后的关系。
选取 2010 年至 2012 年接受手术的 3380 例原发性乳腺癌患者，分为低 BMI 组（BMI<25.0）和高 BMI 组（BMI≥25.0）。从 3178 例患者中获得无病生存（DFS）和总生存（OS）的随访数据（中位随访时间为 58 个月）。采用 Cox 回归分析评估 BMI 对 DFS 和 OS 的影响。
高 BMI 组表现出更具侵袭性的病理特征。BMI 与 OS 呈负相关（风险比（HR）1.33，95%置信区间（CI）1.06-1.66；p=0.012），但与 DFS 无关（HR 1.15，95%CI 0.94-1.40；p=0.17）。此外，按年龄分层时，BMI 与年龄>50 岁患者的 OS 显著负相关（HR 1.43，95%CI 1.05-1.95；p=0.025），但在年轻患者中未发现这种影响。
BMI 是中国女性乳腺癌患者 OS 的独立预后因素，年龄可能是一个缓解因素。在年龄>50 岁的患者中，与 BMI 较低的患者相比，BMI 较高的患者预后较差的风险更高。
