Laboratory of Immunology and Cellular Stress, Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Laboratory of Immunoregulation and Mucosal Immunology, Inflammation Research Center VIB, Ghent, Belgium; GROUP-ID Consortium, Ghent University and University Hospital, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
Curr Opin Immunol. 2018 Jun;52:100-107. doi: 10.1016/j.coi.2018.04.020. Epub 2018 May 11.
The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become clear that the functions of the UPR stretch far beyond their canonical role and intersect with seemingly unrelated functions such as innate immunity and antigen presentation. The aim of the present review is to dissect how the UPR interferes directly and indirectly with the major processes of MHC-I and MHC-II antigen presentation.
未折叠蛋白反应（UPR）是一种适应性反应，旨在恢复内质网应激条件下破坏细胞折叠能力的内质网稳态。在过去的几年中，人们已经清楚地认识到，UPR 的功能远远超出了其典型作用，并与先天免疫和抗原呈递等看似无关的功能相互交叉。本综述的目的是剖析 UPR 如何直接和间接地干扰 MHC-I 和 MHC-II 抗原呈递的主要过程。
