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AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57).AMG 145，一种针对 PCSK9 的单克隆抗体，可帮助高危患者实现国家胆固醇教育计划成人治疗专家组 III 低密度脂蛋白胆固醇目标：来自 LAPLACE-TIMI 57 试验的分析（使用 PCSK9 单克隆抗体抑制联合他汀类药物治疗进行 LDL-C 评估 - 心肌梗死溶栓治疗 57）。
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本文引用的文献

1
Projected Real-World Effectiveness of Using Aggressive Low-Density Lipoprotein Cholesterol Targets Among Elderly Statin Users Following Acute Coronary Syndromes in Canada.加拿大急性冠脉综合征后老年他汀类药物使用者采用强化低密度脂蛋白胆固醇目标的实际效果预测。
J Am Heart Assoc. 2018 May 12;7(10):e007535. doi: 10.1161/JAHA.117.007535.
2
Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis.降脂治疗后 LDL-C 水平与全因及心血管死亡率的相关性：系统评价和荟萃分析。
JAMA. 2018 Apr 17;319(15):1566-1579. doi: 10.1001/jama.2018.2525.
3
Challenges in Interpreting the Lipid-Lowering Trials: Biology vs Ecology.解读降脂试验中的挑战：生物学与生态学
JAMA. 2018 Apr 17;319(15):1549-1551. doi: 10.1001/jama.2018.4041.
4
A Systematic Review and Meta-analysis of the Factors Associated With Nonadherence and Discontinuation of Statins Among People Aged ≥65 Years.一项针对≥65 岁人群中他汀类药物不依从和停药相关因素的系统评价和荟萃分析。
J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):798-805. doi: 10.1093/gerona/glx256.
5
Association of Statin Dose With Amputation and Survival in Patients With Peripheral Artery Disease.他汀类药物剂量与外周动脉疾病患者截肢和生存的关系。
Circulation. 2018 Apr 3;137(14):1435-1446. doi: 10.1161/CIRCULATIONAHA.117.032361. Epub 2018 Jan 12.
6
Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).依泽替米贝联合他汀类药物治疗糖尿病与非糖尿病患者的心血管转归和安全性的获益：来自 IMPROVE-IT（依折麦布减少终点的国际研究）的结果。
Circulation. 2018 Apr 10;137(15):1571-1582. doi: 10.1161/CIRCULATIONAHA.117.030950. Epub 2017 Dec 20.
7
Blood Pressure Trajectories in the 20 Years Before Death.死亡前 20 年的血压轨迹。
JAMA Intern Med. 2018 Jan 1;178(1):93-99. doi: 10.1001/jamainternmed.2017.7023.
8
Trajectory of Total Cholesterol in the Last Years of Life Over Age 80 Years: Cohort Study of 99,758 Participants.80 岁以上人群生命终末期总胆固醇的变化轨迹：99758 名参与者的队列研究。
J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1083-1089. doi: 10.1093/gerona/glx184.
9
Statin Prescribing in the Elderly: Special Considerations.老年人他汀类药物的处方：特殊考量
Curr Atheroscler Rep. 2017 Oct 11;19(11):47. doi: 10.1007/s11883-017-0683-9.
10
Atherogenic Lipoprotein Determinants of Cardiovascular Disease and Residual Risk Among Individuals With Low Low-Density Lipoprotein Cholesterol.低密度脂蛋白胆固醇水平较低个体中动脉粥样硬化性脂蛋白对心血管疾病及残余风险的影响因素
J Am Heart Assoc. 2017 Jul 21;6(7):e005549. doi: 10.1161/JAHA.117.005549.

Reducing Low-Density Lipoprotein Cholesterol After Myocardial Infarction in Older Individuals, Levels Versus Change: Can Observational Studies Answer the Questions?

作者信息

Kuller Lewis H

机构信息

Department of Epidemiology, Graduate School of Public Health University of Pittsburgh, PA

出版信息

J Am Heart Assoc. 2018 May 12;7(10):e009430. doi: 10.1161/JAHA.118.009430.

DOI:10.1161/JAHA.118.009430
PMID:29754126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6015323/
Abstract
摘要