Neuroendocrine Unit, Neuroendocrine Clinical Center, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox 1, Suite 140, Boston, MA 02114, USA.
Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 4, Boston, MA 02114, USA.
Endocrinol Metab Clin North Am. 2018 Jun;47(2):427-440. doi: 10.1016/j.ecl.2018.01.006. Epub 2018 Apr 9.
Medical therapy has a useful adjunctive role in many patients with Cushing's syndrome. Patients with pituitary corticotroph adenomas who have received radiation therapy to the sella require medical therapy until the effects of radiation therapy occur. In addition, patients with Cushing's syndrome who cannot undergo surgery promptly, including those who are acutely ill and cannot safely undergo tumor resection, may benefit from medical therapy as a bridge to surgery. Other possible candidates for medical therapy are those with unresectable tumors or those whose tumor location remains unknown despite adequate diagnostic evaluation.
在许多库欣综合征患者中，医学治疗具有辅助作用。接受鞍区放射治疗的垂体促肾上腺皮质腺瘤患者需要接受医学治疗，直到放射治疗产生效果。此外，那些无法立即手术的库欣综合征患者，包括那些病情危急、无法安全进行肿瘤切除的患者，可能会受益于医学治疗作为手术的桥梁。其他可能适合接受医学治疗的患者包括那些无法切除的肿瘤患者，或尽管经过充分的诊断评估仍无法确定肿瘤位置的患者。
