Eizadi-Mood Nastaran, Halakoei Leila, Yaraghi Ahmad, Jabalameli Mitra, Talakoub Rihanak, Sabzghabaee Ali Mohammad
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Anesthesiology and Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Pharm Pract. 2018 Jan-Mar;7(1):36-40. doi: 10.4103/jrpp.JRPP_18_8.
Bispectral index (BIS) is one of the several methods used to monitor the depth of anesthesia. Poisoning with ingestion of different drugs is one of the most common poisonings that have different clinical signs from drowsiness to coma. This study was performed to compare the BIS index number in poisoned patients with multi drugs ingestion with or without the need for endotracheal intubation.
This cross-sectional study was performed on poisoned patients with ingestion of different drugs referring to Clinical Toxicology Department of Noor University Hospital, Isfahan, Iran. The clinical signs and symptoms and the vital signs at the admission time were measured, and the required therapies were given. The endotracheal intubation was done for patients who had the indication of intubation. BIS was monitored and compared for all patients with or without a need for intubation on the admission time and time of endotracheal intubation. Obtained data were analyzed by SPSS software.
At the admission time, the mean (standard error [SE]) BIS index value for poisoned patients who needed endotracheal intubation was 66.47 ± 2.57 in comparison with 85.21 ± 1.47 for patients who did not need intubation ( < 0.001). The results of receiver operating characteristic curve (mean ± SE) showed the discrimination was excellent for BIS (0.899 ± 0.04; 95% confidence interval: 0.81-0.98) ( < 0.0001). BIS <79.5 had the sensitivity 88% and specificity 87% for endotracheal intubation.
BIS is an appropriate index for prediction of the need to intubation in poisoned patients with ingestion of different drugs.
脑电双频指数（BIS）是用于监测麻醉深度的几种方法之一。摄入不同药物导致的中毒是最常见的中毒类型之一，其临床症状从嗜睡到昏迷各不相同。本研究旨在比较多药摄入中毒患者在需要或不需要气管插管情况下的BIS指数值。
本横断面研究对转诊至伊朗伊斯法罕努尔大学医院临床毒理学科的不同药物摄入中毒患者进行。测量入院时的临床症状和体征以及生命体征，并给予所需治疗。对有插管指征的患者进行气管插管。对所有患者在入院时和气管插管时监测并比较BIS，无论是否需要插管。所得数据采用SPSS软件进行分析。
入院时，需要气管插管的中毒患者的平均（标准误[SE]）BIS指数值为66.47±2.57，而不需要插管的患者为85.21±1.47（P<0.001）。受试者工作特征曲线（均值±SE）结果显示，BIS的辨别能力极佳（0.899±0.04；95%置信区间：0.81 - 0.98）（P<0.0001）。BIS<79.5对气管插管的敏感性为88%，特异性为87%。
BIS是预测不同药物摄入中毒患者是否需要插管的合适指标。
