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Severe decrease in SpO and methemoglobinemia following subareolar isosulfan blue administration and clinical relevance.乳晕下注射异硫蓝后SpO严重下降及高铁血红蛋白血症与临床相关性
Turk J Surg. 2018 Mar 1;34(1):74-76. doi: 10.5152/turkjsurg.2017.3137. eCollection 2018.
2
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Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer.乳腺癌前哨淋巴结活检期间对异硫蓝染料的过敏反应。
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Eur J Breast Health. 2025 Jan 1;21(1):1-8. doi: 10.4274/ejbh.galenos.2024.2024-8-1.
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A Case of Acquired Methemoglobinemia Following Sentinel Lymph Node Dye With Patent Blue V.一例使用专利蓝V进行前哨淋巴结染色后获得性高铁血红蛋白血症病例。
Cureus. 2024 Nov 18;16(11):e73897. doi: 10.7759/cureus.73897. eCollection 2024 Nov.

本文引用的文献

1
Sentinel Node and Recurrent Breast Cancer (SNARB): results of a nationwide registration study.前哨淋巴结与复发性乳腺癌（SNARB）：一项全国性登记研究的结果。
Ann Surg Oncol. 2013 Feb;20(2):620-6. doi: 10.1245/s10434-012-2625-7. Epub 2012 Sep 1.
2
Interference of patent blue dye with pulse oximetry readings, methemoglobin measurements, and blue urine in sentinel lymph node mapping: a case report and review of the literature.专利蓝染料对前哨淋巴结定位中脉搏血氧饱和度读数、高铁血红蛋白测量及蓝色尿液的干扰：一例病例报告及文献复习
Acta Anaesthesiol Taiwan. 2011 Dec;49(4):162-4. doi: 10.1016/j.aat.2011.11.004. Epub 2011 Dec 19.
3
Isosulfan blue-induced anaphylactic reaction during sentinel lymph node biopsy in breast cancer.乳腺癌前哨淋巴结活检术中异硫蓝引发的过敏反应
Breast. 2012 Apr;21(2):220-2. doi: 10.1016/j.breast.2011.11.008. Epub 2011 Dec 19.
4
Methemoglobinemia: pathogenesis, diagnosis, and management.高铁血红蛋白血症：发病机制、诊断与管理
South Med J. 2011 Nov;104(11):757-61. doi: 10.1097/SMJ.0b013e318232139f.
5
Anaphylaxis to patent blue V: a case series and proposed diagnostic protocol.专利蓝 V 过敏：病例系列及诊断方案建议。
Allergy. 2010 Mar;65(3):396-400. doi: 10.1111/j.1398-9995.2009.02248.x. Epub 2009 Nov 20.
6
Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes.对异硫蓝过敏及与专利蓝V交叉反应：病例报告及活性蓝色染料命名法综述
Ann Allergy Asthma Immunol. 2006 Mar;96(3):497-500. doi: 10.1016/S1081-1206(10)60921-0.
7
Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery.用于辅助乳腺癌手术中腋窝前哨淋巴结定位的注射染料的性质和特性。
Eur J Surg Oncol. 2006 May;32(4):381-4. doi: 10.1016/j.ejso.2006.01.010. Epub 2006 Mar 2.
8
Isosulfan blue causes factitious methemoglobinemia in an infant.异硫蓝导致一名婴儿出现假性高铁血红蛋白血症。
Paediatr Anaesth. 2005 Dec;15(12):1116-9. doi: 10.1111/j.1460-9592.2005.01578.x.
9
Interference of patent blue V dye with pulse oximetry and co-oximetry.专利蓝V染料对脉搏血氧饱和度测定法和血气分析仪的干扰。
Eur J Anaesthesiol. 2005 Jun;22(6):475-6. doi: 10.1017/s0265021505230818.
10
[False decrease in pulse oximetry readings due to patent blue in a patient with breast cancer].
Masui. 2003 Aug;52(8):909-11.

乳晕下注射异硫蓝后SpO严重下降及高铁血红蛋白血症与临床相关性

Severe decrease in SpO and methemoglobinemia following subareolar isosulfan blue administration and clinical relevance.

作者信息

Yüksel Esra, Duman Dilek, Yeniay Levent, Ulukaya Sezgin

机构信息

Department of Anesthesiology and Reanimation, Ege University School of Medicine, İzmir, Turkey.

Department of General Surgery, Ege University School of Medicine, İzmir, Turkey.

出版信息

Turk J Surg. 2018 Mar 1;34(1):74-76. doi: 10.5152/turkjsurg.2017.3137. eCollection 2018.

DOI:10.5152/turkjsurg.2017.3137
PMID:29756115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5937668/
Abstract

The level of axillary lymph node involvement in breast cancer is a critical decision factor for adjuvant therapy and the most important indicator of prognosis and survival. Sentinel lymph node biopsy is a minimally invasive technique with low morbidity in axillary staging of breast cancer. Radiocolloid substances (Technetium-99m) and/or blue dyes such as methylene blue or isosulfan blue are used during sentinel lymph node biopsy. Isosulfan blue stain is frequently used in sentinel lymph node biopsy and rarely causes complications. The present case report presents a severe decrease in SpO2 due to methemoglobinemia following isosulfan blue administration as well as skin and urine signs and inconsistency with clinical picture in a 67-year-old, 77 kg, ASA II female case who underwent sentinel lymph node biopsy under general anesthesia.

摘要

乳腺癌腋窝淋巴结受累程度是辅助治疗的关键决定因素，也是预后和生存的最重要指标。前哨淋巴结活检是一种微创技术，在乳腺癌腋窝分期中发病率较低。在前哨淋巴结活检过程中使用放射性胶体物质（锝-99m）和/或蓝色染料，如亚甲蓝或异硫蓝。异硫蓝染色在前哨淋巴结活检中经常使用，很少引起并发症。本病例报告介绍了一名67岁、体重77kg、ASA II级的女性患者，在全身麻醉下接受前哨淋巴结活检后，因异硫蓝给药后出现高铁血红蛋白血症导致SpO2严重下降，以及皮肤和尿液体征与临床表现不一致的情况。