Lai Hou-Chuan, Hsu Huan-Ming, Cherng Chen-Hwan, Lin Shinn-Long, Wu Ching-Tang, Yu Jyh-Cherng, Yeh Chun-Chang
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Acta Anaesthesiol Taiwan. 2011 Dec;49(4):162-4. doi: 10.1016/j.aat.2011.11.004. Epub 2011 Dec 19.
Patent blue (PB) dye has been successfully used worldwide in breast and cervix surgeries with few complications. Interference of oxyhemoglobin saturation reading by pulse oximetry (SpO(2)) and methemoglobinemia, from injection of PB dye, have rarely been reported in breast and cervix surgeries. We report here the first case of interference of SpO(2) reading, advent of methemoglobinemia, and blue urine from the use of PB dye, which occurred concurrently in a female undergoing bilateral modified radical mastectomy. The unexpected events might be a consequence of excessive administration of PB dye. We also reviewed the published discourses in literature on the adverse effects of PB dye.
专利蓝（PB）染料已在全球范围内成功应用于乳房和子宫颈手术，并发症较少。在乳房和子宫颈手术中，很少有关于注射PB染料导致脉搏血氧饱和度（SpO₂）读数受干扰和高铁血红蛋白血症的报道。我们在此报告首例在一位接受双侧改良根治性乳房切除术的女性患者中同时出现SpO₂读数受干扰、高铁血红蛋白血症以及蓝色尿液的情况，这是使用PB染料所致。这些意外事件可能是PB染料过量使用的结果。我们还回顾了文献中已发表的关于PB染料不良反应的论述。
