College of Medicine, Qatar University, Doha, Qatar.
Biomedical Research Centre, Qatar University, Doha, Qatar.
Head Neck. 2018 Oct;40(10):2166-2171. doi: 10.1002/hed.25210. Epub 2018 May 13.
Today, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored.
The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes.
Our data revealed that cell-phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E-cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models.
Our investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation.
如今，手机是全球普及度最高的技术。然而，手机射频对头颈部癌症进展的影响尚未得到探索。
我们使用鸡胚尿囊膜（CAM）和人头颈癌细胞系 FaDu 和 SCC25，分别研究手机射频对血管生成、头颈癌细胞侵袭和集落形成的影响。采用 Western blot 分析研究手机对 E-钙黏蛋白和 Erk1/Erk2 基因调控的影响。
我们的数据显示，手机射频促进了 CAM 的血管生成。此外，手机增强了人头颈癌细胞的侵袭和集落形成能力，同时下调了 E-钙黏蛋白的表达。更重要的是，我们发现手机可以在我们的实验模型中激活 Erk1/Erk2。
我们的研究表明，手机射频可能通过激活 Erk1/Erk2 来刺激血管生成和细胞侵袭，从而增强头颈部癌症的发生。
