Department of Mechanics and Design, Kookmin University, Seoul 136-702, Korea.
School of Mechanical Engineering, Kookmin University, Seoul 136-702, Korea.
Sensors (Basel). 2018 May 14;18(5):1547. doi: 10.3390/s18051547.
Breath analysis has become increasingly important as a noninvasive process for the clinical diagnosis of patients suffering from various diseases. Many commercial gas preconcentration instruments are already being used to overcome the detection limits of commercial gas sensors for gas concentrations which are as low as ~100 ppb in exhaled breath. However, commercial instruments are large and expensive, and they require high power consumption and intensive maintenance. In the proposed study, a micro gas preconcentrator (μ-PC) filled with a carbon nanotube (CNT) foam as an adsorbing material was designed and fabricated for the detection of low-concentration ethane, which is known to be one of the most important biomarkers related to chronic obstructive pulmonary disease (COPD) and asthma. A comparison of the performance of two gas-adsorbing materials, i.e., the proposed CNT foam and commercial adsorbing material, was performed using the developed μ-PC. The experimental results showed that the synthesized CNT foam performs better than a commercial adsorbing material owing to its lower pressure drop and greater preconcentration efficiency in the μ-PC. The present results show that the application of CNT foam-embedded μ-PC in portable breath analysis systems holds great promise.
呼气分析作为一种非侵入性的临床诊断方法,在诊断各种疾病的患者方面变得越来越重要。许多商业气体预浓缩仪器已经被用于克服商业气体传感器对呼气中低至约 100ppb 的气体浓度的检测限。然而,商业仪器体积大且昂贵,需要高功耗和密集的维护。在拟议的研究中,设计并制造了一种填充有碳纳米管(CNT)泡沫的微型气体预浓缩器(μ-PC),用于检测乙烷,乙烷是与慢性阻塞性肺疾病(COPD)和哮喘等相关的最重要的生物标志物之一。使用开发的 μ-PC 对两种气体吸附材料,即提议的 CNT 泡沫和商业吸附材料的性能进行了比较。实验结果表明,由于其在 μ-PC 中的压降更低且预浓缩效率更高,合成的 CNT 泡沫的性能优于商业吸附材料。目前的结果表明,将嵌入 CNT 泡沫的 μ-PC 应用于便携式呼吸分析系统具有广阔的前景。