便携式呼吸丙酮分析用于糖尿病检测。
Toward portable breath acetone analysis for diabetes detection.
机构信息
Particle Technology Laboratory, Department of Mechanical and Process Engineering, Institute of Process Engineering, ETH Zurich CH-8092 Zurich, Switzerland.
出版信息
J Breath Res. 2011 Sep;5(3):037109. doi: 10.1088/1752-7155/5/3/037109. Epub 2011 Aug 9.
Abstract
Diabetes is a lifelong condition that may cause death and seriously affects the quality of life of a rapidly growing number of individuals. Acetone is a selective breath marker for diabetes that may contribute to the monitoring of related metabolic disorder and thus simplify the management of this illness. Here, the overall performance of Si-doped WO(3) nanoparticles, made by flame spray pyrolysis, as portable acetone detectors is critically reviewed focusing on the requirements for medical diagnostics. The effect of flow rate, chamber volume and acetone dissociation within the measuring chamber is discussed with respect to the calibration of the sensor response. The challenges for the fabrication of portable breath acetone sensors based on chemo-resistive detectors are underlined indicating possible solutions and novel research directions.
摘要
糖尿病是一种终身疾病，可能导致死亡，并严重影响数量迅速增长的个人的生活质量。丙酮是糖尿病的一种选择性呼吸标志物，它可能有助于监测相关的代谢紊乱，从而简化这种疾病的管理。在这里，通过火焰喷雾热解法制备的 Si 掺杂 WO(3)纳米粒子作为便携式丙酮探测器的整体性能，根据医疗诊断的要求进行了严格的审查。讨论了流速、腔室体积和测量腔内丙酮离解对传感器响应校准的影响。强调了基于化学电阻探测器的便携式呼吸丙酮传感器制造所面临的挑战，指出了可能的解决方案和新的研究方向。
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