使用[3H]帕罗西汀（一种新型血清素摄取抑制剂）测量血清素摄取位点。
Measuring the serotonin uptake site using [3H]paroxetine--a new serotonin uptake inhibitor.
作者信息
Gleiter C H, Nutt D J
机构信息
Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
出版信息
Adv Alcohol Subst Abuse. 1988;7(3-4):107-11. doi: 10.1300/J251v07n03_17.
PMID:2975918
Abstract
Serotonin is an important neurotransmitter that may be involved in ethanol preference and dependence. It is possible to label the serotonin uptake site in brain using the tricyclic antidepressant imipramine, but this also binds to other sites. We have used the new high-affinity uptake blocker paroxetine to define binding to this site and report it to have advantages over imipramine as a ligand.
摘要
血清素是一种重要的神经递质，可能与乙醇偏好和依赖有关。使用三环类抗抑郁药丙咪嗪可以标记大脑中的血清素摄取位点，但它也会与其他位点结合。我们使用了新型高亲和力摄取阻滞剂帕罗西汀来确定与该位点的结合，并报告其作为配体比丙咪嗪具有优势。
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