Centre for Cancer Research and Cell BiologyQueen's University of Belfast, Belfast, UK.
Centre for Cancer Research and Cell BiologyQueen's University of Belfast, Belfast, UK
Endocr Relat Cancer. 2018 Sep;25(9):R435-R452. doi: 10.1530/ERC-18-0048. Epub 2018 May 14.
Metabolic dysregulation is regarded as an important driver in cancer development and progression. The impact of transcriptional changes on metabolism has been intensively studied in hormone-dependent cancers, and in particular, in prostate and breast cancer. These cancers have strong similarities in the function of important transcriptional drivers, such as the oestrogen and androgen receptors, at the level of dietary risk and epidemiology, genetics and therapeutically. In this review, we will focus on the function of these nuclear hormone receptors and their downstream impact on metabolism, with a particular focus on lipid metabolism. We go on to discuss how lipid metabolism remains dysregulated as the cancers progress. We conclude by discussing the opportunities that this presents for drug repurposing, imaging and the development and testing of new therapeutics and treatment combinations.
代谢失调被认为是癌症发展和进展的重要驱动因素。转录变化对代谢的影响在激素依赖性癌症中得到了深入研究，特别是在前列腺癌和乳腺癌中。这些癌症在饮食风险和流行病学、遗传学和治疗学方面的重要转录驱动因素（如雌激素和雄激素受体）的功能上具有很强的相似性。在这篇综述中，我们将重点讨论这些核激素受体的功能及其对代谢的下游影响，特别是脂质代谢。我们接着讨论了随着癌症的进展，脂质代谢如何仍然失调。最后，我们讨论了这为药物重新利用、成像以及新疗法和治疗组合的开发和测试带来的机会。
