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[伴外生性生长的脊髓髓内肿瘤]

[Spinal intramedullary tumor with exophytic growth].

作者信息

Ishikawa T, Iwasaki Y, Isu T, Akino M, Koyanagi I, Hida K, Abe H, Miyasaka K, Abe S

机构信息

Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

No Shinkei Geka. 1988 Nov;16(12):1339-45.

PMID:2976124
Abstract

We experienced 22 cases of spinal intramedullary tumor, in which 5 cases were accompanied with exophytic growth. We discussed their clinical and radiological features, and therapeutic problems. Concerning the locations of tumors with exophytic growth, the most common site was conus medullaris, accounting for 60% (3 cases). Histopathological findings were astrocytoma in two cases, and in one case, mixed glioma, ependymoma and hemangioblastoma. In neurological observation, the most common initial symptom was back pain and lumbago, suggesting root pain. No neurological features distinguishable from those of extramedullary tumors were presented. In radiological examination, myelography and CT myelography were very helpful for diagnosis. Myelography and CT myelography showed extramedullary mass, shift and deformity of spinal cord that was not serious as compared with the size of extramedullary mass, and showed the portion where the spinal cord was swollen. Good outcomes were obtained in a case with total removal, and two cases with subtotal and partial removal that were managed with additional irradiation and chemotherapy. However recurrence and intracranial seeding made prognosis poor in two cases where total removal was impossible. We thought that postoperative careful follow-up was necessary not only to detect recurrence but also to detect intracranial seeding in the cases of spinal intramedullary tumor with exophytic growth.

摘要

我们收治了22例脊髓髓内肿瘤患者,其中5例伴有外生性生长。我们讨论了其临床和影像学特征以及治疗问题。关于伴有外生性生长的肿瘤的位置,最常见的部位是圆锥,占60%(3例)。组织病理学检查结果显示,2例为星形细胞瘤,1例为混合性胶质瘤、室管膜瘤和血管母细胞瘤。在神经学观察中,最常见的初始症状是背痛和腰痛,提示神经根痛。未表现出与髓外肿瘤不同的神经学特征。在影像学检查中,脊髓造影和CT脊髓造影对诊断非常有帮助。脊髓造影和CT脊髓造影显示髓外肿块、脊髓移位和变形,与髓外肿块大小相比不严重,并显示脊髓肿胀的部位。1例全切除、2例次全切除和部分切除并辅以放疗和化疗的患者取得了良好的效果。然而,在2例无法全切除的病例中,复发和颅内播散导致预后不良。我们认为,对于伴有外生性生长的脊髓髓内肿瘤患者,术后仔细随访不仅有必要检测复发,而且有必要检测颅内播散。

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