Asaleye Adesola Abiodun, Braimoh Kolawole Thomas, Oyinloye Olalekan Ibukun, Asaleye Christianah Mopelola, Omisore Adeleye Dorcas
Department of Radiology, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Department of Radiology, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
J Ultrasound Med. 2019 Jan;38(1):123-130. doi: 10.1002/jum.14673. Epub 2018 May 15.
Studies have shown that common carotid intima media thickness (CIMT) measured by B-mode sonography increases with body mass index (BMI) among subjects with cardiovascular diseases in different populations. However, association of body fat and subclinical atherosclerosis in the absence of these cardiovascular diseases is understudied. We aimed to evaluate the correlation between BMI and CIMT in a healthy adult population of black African ancestry.
This is a cross-sectional prospective study in 300 consecutive apparently healthy subjects aged 18 to 70 years without history of hypertension, dyslipidemia, diabetes mellitus, and renal disease. Subjects' common carotid artery intima media thickness was measured with a 7.5-MHz linear ultrasound transducer at a point 10 mm proximal to the carotid bulb. All subjects' biodata, medical history, anthropometric (weight and height from which BMI was calculated), laboratory (fasting lipid profile and blood glucose), and CIMT values were recorded on a pro forma. Data were analysed using SPSS version 21, and significant P was set at less than .05.
The right, left, and average CIMT of both sides in our study subjects are 0.52 ± 0.11 mm, 0.51 ± 0.11 mm and 0.52 ± 0.11 mm respectively, with no significant difference between the right and left sides (P > .05). The right, left, and average CIMT increased with increasing age and BMI category (all P < .01) but were not significantly different between men and women (all P > .05). Age (r = .824, .825, and .827; P < .01) and BMI (r = .503, .504, .507; P < .01) had strong positive correlations with right, left, and average CIMT.
Increasing age and BMI category, but not sex, significantly influenced CIMT values in our apparently healthy black African population.
研究表明，在不同人群中，通过B型超声测量的颈总动脉内膜中层厚度（CIMT）在患有心血管疾病的受试者中会随着体重指数（BMI）的增加而增加。然而，在没有这些心血管疾病的情况下，体脂与亚临床动脉粥样硬化之间的关联研究较少。我们旨在评估非洲裔健康成年人群中BMI与CIMT之间的相关性。
这是一项横断面前瞻性研究，连续纳入300名年龄在18至70岁之间、无高血压、血脂异常、糖尿病和肾病病史的明显健康受试者。使用7.5兆赫线性超声换能器在颈动脉窦近端10毫米处测量受试者的颈总动脉内膜中层厚度。所有受试者的生物数据、病史、人体测量数据（计算BMI所需的体重和身高）、实验室数据（空腹血脂谱和血糖）以及CIMT值都记录在一份表格上。使用SPSS 21版软件进行数据分析，显著P值设定为小于0.05。
我们研究对象两侧的右侧、左侧及平均CIMT分别为0.52±0.11毫米、0.51±0.11毫米和0.52±0.11毫米，左右两侧之间无显著差异（P>0.05）。右侧、左侧及平均CIMT均随年龄和BMI类别增加而增加（所有P<0.01），但男女之间无显著差异（所有P>0.05）。年龄（r = 0.824、0.825和0.827；P<0.01）和BMI（r = 0.503、0.504、0.507；P<0.01）与右侧、左侧及平均CIMT均呈强正相关。
在我们明显健康的非洲裔人群中，年龄和BMI类别增加，但性别未对CIMT值产生显著影响。
