• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease.

作者信息

Zhao Zi-Wei, Yuan Zhen, Zhao De-Qiang, Wang Zhan-Wen, Zhu Fei-Qi, Luan Ping

机构信息

Medical Center, Shenzhen University Health Science Center, Shenzhen, China.

Faculty of Health Sciences, University of Macau, Macau, China.

出版信息

CNS Neurosci Ther. 2018 Sep;24(9):837-840. doi: 10.1111/cns.12861. Epub 2018 May 14.

DOI:10.1111/cns.12861
PMID:29761665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6490093/
Abstract
摘要

相似文献

1
The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease.V-ATP酶功能缺陷在阿尔茨海默病发病机制中的作用。
CNS Neurosci Ther. 2018 Sep;24(9):837-840. doi: 10.1111/cns.12861. Epub 2018 May 14.
2
Low-n oligomers as therapeutic targets of Alzheimer's disease.低聚物作为阿尔茨海默病的治疗靶点。
J Neurochem. 2011 Apr;117(1):19-28. doi: 10.1111/j.1471-4159.2011.07187.x. Epub 2011 Feb 9.
3
Amyloid fibril polymorphism and cell-specific toxicity .淀粉样纤维多态性与细胞特异性毒性
Amyloid. 2019;26(sup1):136-137. doi: 10.1080/13506129.2019.1582488.
4
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide.单点突变诱导阿尔茨海默病相关 Aβ42 肽聚集的分子机制发生转变。
ACS Chem Biol. 2014 Feb 21;9(2):378-82. doi: 10.1021/cb400616y. Epub 2013 Nov 25.
5
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.用于阿尔茨海默病淀粉样斑块分子靶向的 6 肽淀粉样β蛋白衍生噬菌体展示文库的设计与评价：与源自随机噬菌体展示文库的两个环状七肽的比较。
Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.
6
Protein twists and turns in Alzheimer disease.阿尔茨海默病中的蛋白质扭曲与转折
Nat Med. 2006 Apr;12(4):392-3. doi: 10.1038/nm0406-392.
7
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells.阿尔茨海默病 APP 转基因小鼠模型中缺乏功能性 B 和 T 细胞导致 β-淀粉样蛋白病理减少。
Acta Neuropathol Commun. 2015 Nov 11;3:71. doi: 10.1186/s40478-015-0251-x.
8
[Alzheimer's disease due to presenilin mutations].早老素突变所致阿尔茨海默病
Nihon Rinsho. 2004 Jan;62 Suppl:90-4.
9
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".对《β淀粉样肽与α-突触核蛋白之间的相互作用：路易体痴呆中阿尔茨海默病和帕金森病重叠病理的分子机制》的评论
Neurochem Res. 2008 Jun;33(6):1168. doi: 10.1007/s11064-007-9553-0.
10
Alzheimer's amyloid story finds its star.阿尔茨海默病淀粉样蛋白的故事找到了主角。
Trends Mol Med. 2006 Sep;12(9):395-6. doi: 10.1016/j.molmed.2006.07.002. Epub 2006 Aug 1.

引用本文的文献

1
Advance and Prospect of Positron Emission Tomography in Alzheimer's disease research.正电子发射断层扫描在阿尔茨海默病研究中的进展与展望
Mol Psychiatry. 2025 Jun 21. doi: 10.1038/s41380-025-03081-2.
2
Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment.对Tg2576阿尔茨海默病小鼠海马体和视网膜的转录组分析揭示了线粒体氧化磷酸化缺陷以及Tau 12A12单克隆抗体治疗后的恢复情况。
Cells. 2023 Sep 12;12(18):2254. doi: 10.3390/cells12182254.
3
Protect Effects of Seafood-Derived Plasmalogens Against Amyloid-Beta (1-42) Induced Toxicity via Modulating the Transcripts Related to Endocytosis, Autophagy, Apoptosis, Neurotransmitter Release and Synaptic Transmission in SH-SY5Y Cells.海鲜源缩醛磷脂通过调节SH-SY5Y细胞中与内吞作用、自噬、凋亡、神经递质释放和突触传递相关的转录本对β-淀粉样蛋白（1-42）诱导的毒性的保护作用。
Front Aging Neurosci. 2021 Nov 26;13:773713. doi: 10.3389/fnagi.2021.773713. eCollection 2021.

本文引用的文献

1
Regulatory factor X1 depresses ApoE-dependent Aβ uptake by miRNA-124 in microglial response to oxidative stress.在小胶质细胞对氧化应激的反应中，调节因子X1通过微小RNA-124抑制载脂蛋白E依赖的β淀粉样蛋白摄取。
Neuroscience. 2017 Mar 6;344:217-228. doi: 10.1016/j.neuroscience.2016.12.017. Epub 2016 Dec 18.
2
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.溶酶体酸化紊乱——V-ATP酶在衰老和神经退行性疾病中的新作用
Ageing Res Rev. 2016 Dec;32:75-88. doi: 10.1016/j.arr.2016.05.004. Epub 2016 May 16.
3
The amyloid hypothesis of Alzheimer's disease at 25 years.阿尔茨海默病淀粉样蛋白假说25年回顾
EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun.
4
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation.精氨酸酶1阳性小胶质细胞在白细胞介素-1β依赖性神经炎症过程中减少β淀粉样蛋白斑块沉积。
J Neuroinflammation. 2015 Nov 4;12:203. doi: 10.1186/s12974-015-0411-8.
5
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.小胶质细胞通过溶酶体降解阿尔茨海默病淀粉样纤维需要 ClC-7 的转运。
Mol Biol Cell. 2011 May 15;22(10):1664-76. doi: 10.1091/mbc.E10-09-0745. Epub 2011 Mar 25.
6
The role of microglia in amyloid clearance from the AD brain.小胶质细胞在 AD 脑中淀粉样蛋白清除中的作用。
J Neural Transm (Vienna). 2010 Aug;117(8):949-60. doi: 10.1007/s00702-010-0433-4. Epub 2010 Jun 15.
7
Autophagy fights disease through cellular self-digestion.自噬通过细胞自我消化来对抗疾病。
Nature. 2008 Feb 28;451(7182):1069-75. doi: 10.1038/nature06639.
8
Autophagy, amyloidogenesis and Alzheimer disease.自噬、淀粉样蛋白生成与阿尔茨海默病。
J Cell Sci. 2007 Dec 1;120(Pt 23):4081-91. doi: 10.1242/jcs.019265.
9
Intracellular amyloid-beta in Alzheimer's disease.阿尔茨海默病中的细胞内β淀粉样蛋白
Nat Rev Neurosci. 2007 Jul;8(7):499-509. doi: 10.1038/nrn2168.
10
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.内体/溶酶体系统在β淀粉样蛋白生成及阿尔茨海默病病理生理学中的作用：从溶酶体角度重新审视空间悖论。
J Alzheimers Dis. 2004 Feb;6(1):53-65. doi: 10.3233/jad-2004-6107.