化妆品中使用的水解小麦蛋白和水解小麦面筋的安全性评估。

Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics.

作者信息

Burnett Christina, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Andersen F Alan, Heldreth Bart

机构信息

1 Scientific Analyst/Writer, Cosmetic Ingredient Review, Cosmetic Ingredient Review, Washington, DC, USA.

2 Expert Panel Member, Cosmetic Ingredient Review, Cosmetic Ingredient Review, Washington, DC, USA.

出版信息

Int J Toxicol. 2018 May/Jun;37(1_suppl):55S-66S. doi: 10.1177/1091581818776013.

DOI:10.1177/1091581818776013

PMID:29761728

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids. The Panel concluded that hydrolyzed wheat gluten and hydrolyzed wheat protein are safe for use in cosmetics when formulated to restrict peptides to an average molecular weight of 3,500 Da or less.

摘要

化妆品成分审查（CIR）专家小组（小组）审查了用作皮肤和头发调理剂的水解小麦蛋白和水解小麦麸质的产品用途、配方及安全性数据。小组确定，临床和实验室研究数据足以证明，这些成分不会在致敏个体中引发1型速发型超敏反应，并且当水解产物的多肽长度不超过30个氨基酸时不会诱导致敏。小组得出结论，当配方将肽限制在平均分子量3500道尔顿或更低时，水解小麦麸质和水解小麦蛋白用于化妆品是安全的。