Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States.
Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, United States.
Elife. 2018 May 15;7:e33505. doi: 10.7554/eLife.33505.
The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice. We show that POA Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis. However, POA leptin signaling is not involved in ambient temperature-dependent metabolic adaptations. Our study reveals a novel cell population through which leptin regulates body weight.
脂肪细胞因子瘦素作用于大脑以调节能量平衡,但许多大脑区域的具体功能仍知之甚少。在这些区域中,视前区(POA)通过控制棕色脂肪产热来调节核心体温,我们之前已经表明,POA 中的谷氨酸能、长形式瘦素受体(Lepr)表达神经元受温暖环境温度刺激,并抑制能量消耗和食物摄入。在这里,我们进一步研究了 POA 瘦素信号在小鼠体重调节中的作用及其与体温调节的关系。我们表明,POA Lepr 信号通过响应内部能量状态来调节能量消耗,从而有助于体重平衡。然而,POA 瘦素信号不参与环境温度依赖性的代谢适应。我们的研究揭示了一个新的细胞群体,通过该群体瘦素调节体重。