State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, 300071, P. R. China.
Chemistry. 2018 Jul 2;24(37):9269-9273. doi: 10.1002/chem.201801886. Epub 2018 May 30.
A photoredox-catalyzed umpolung strategy for coupling reactions between aldehydes, ketones, imines, and N-arylamines is reported. These reactions proceed by a Brønsted acid-activated proton-coupled electron transfer pathway, and the protocol was used to synthesize a broad scope of 1,2-amino alcohols and vicinal diamines, both of which are common motifs in biologically active natural products, pharmaceutically active molecules, and ligands.
本文报道了一种光氧化还原催化的醛、酮、亚胺和 N-芳基胺之间的偶联反应的反转策略。这些反应通过 Brønsted 酸激活的质子耦合电子转移途径进行，该方案用于合成广泛的 1,2-氨基醇和偕二胺，它们都是生物活性天然产物、药物活性分子和配体中常见的结构单元。
