可见光光氧化还原催化下二氢喹喔啉-2-酮与三氟甲基酮的自由基加成反应
Radical Addition of Dihydroquinoxalin-2-ones to Trifluoromethyl Ketones under Visible-Light Photoredox Catalysis.
作者信息
Rostoll-Berenguer Jaume, Martín-López María, Blay Gonzalo, Pedro José R, Vila Carlos
机构信息
Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner 50, 46100 Burjassot, València, Spain.
出版信息
J Org Chem. 2022 Jul 15;87(14):9343-9356. doi: 10.1021/acs.joc.2c01139. Epub 2022 Jul 5.
A visible-light photocatalytic radical addition reaction of dihydroquinoxalin-2-ones to trifluoromethyl ketones has been established using Ru(bpy)Cl as photocatalyst, acetonitrile as solvent, and HP Single Blue LED as the source of light. The reaction provides a straightforward approach to the synthesis of dihydroquinoxalin-2-ones bearing a trifluoromethyl-substituted tertiary alcohol moiety in moderate to good yields under mild conditions.
以Ru(bpy)Cl为光催化剂、乙腈为溶剂、HP单蓝光发光二极管为光源，建立了二氢喹喔啉-2-酮与三氟甲基酮的可见光光催化自由基加成反应。该反应提供了一种直接的方法，可在温和条件下以中等至良好的产率合成带有三氟甲基取代叔醇部分的二氢喹喔啉-2-酮。
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