Bao Zengtao, Wang Tong
Department of Gastrointestinal Surgery, Lianyungang First People's Hospital, Affiliated Hospital of Clinical Medical School to Nanjing Medical University, Lianyungang, Jiangsu 222002, P.R.China;Department of Endoscopy Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R.China.
Department of Endoscopy Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Oct 1;34(5):807-811. doi: 10.7507/1001-5515.201701012.
Ultra-sensitive and quantitative analysis of proteins, nucleic acid, virus and other biochemical species are critical technologies for effective dianosis of disease, as well as medical studies. Silicon nanowires field-effect transistor (SiNWs-FET) biosensor is one of the most promising powerful platforms for label-free, real-time, ultra-sensitive detection of analyte. Here, the working principle of SiNWs-FET biosensor and the applications of SiNWs-FET biosensors in medicine were introduced. Moreover, the methods for enhancing the sensitivity of SiNWs-FET biosensor were discussed. Lastly, the prospecting of SiNWs-FET biosensor was presented.
对蛋白质、核酸、病毒及其他生物化学物质进行超灵敏和定量分析，是疾病有效诊断及医学研究的关键技术。硅纳米线场效应晶体管（SiNWs-FET）生物传感器是用于无标记、实时、超灵敏检测分析物的最具潜力的强大平台之一。本文介绍了SiNWs-FET生物传感器的工作原理及其在医学中的应用。此外，还讨论了提高SiNWs-FET生物传感器灵敏度的方法。最后，对SiNWs-FET生物传感器进行了展望。
