Ministry of Education Engineering Research Center of Smart Microsensors and Microsystems, School of Electronic Information, Hangzhou Dianzi University, Hangzhou 310018, China.
The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China.
Sensors (Basel). 2023 Jul 30;23(15):6808. doi: 10.3390/s23156808.
As a new type of one-dimensional semiconductor nanometer material, silicon nanowires (SiNWs) possess good application prospects in the field of biomedical sensing. SiNWs have excellent electronic properties for improving the detection sensitivity of biosensors. The combination of SiNWs and field effect transistors (FETs) formed one special biosensor with high sensitivity and target selectivity in real-time and label-free. Recently, SiNW-FETs have received more attention in fields of biomedical detection. Here, we give a critical review of the progress of SiNW-FETs, in particular, about the reversible surface modification methods. Moreover, we summarized the applications of SiNW-FETs in DNA, protein, and microbial detection. We also discuss the related working principle and technical approaches. Our review provides an extensive discussion for studying the challenges in the future development of SiNW-FETs.
作为一种新型的一维半导体纳米材料，硅纳米线（SiNWs）在生物医学传感领域具有良好的应用前景。SiNWs 具有优异的电子性能，可提高生物传感器的检测灵敏度。SiNWs 与场效应晶体管（FETs）结合形成了一种特殊的生物传感器，具有高灵敏度和实时、无标记的目标选择性。最近，SiNW-FETs 在生物医学检测领域受到了更多的关注。在这里，我们对 SiNW-FETs 的进展进行了批判性的回顾，特别是关于其可逆表面修饰方法。此外，我们总结了 SiNW-FETs 在 DNA、蛋白质和微生物检测中的应用。我们还讨论了相关的工作原理和技术方法。我们的综述为研究 SiNW-FETs 未来发展中的挑战提供了广泛的讨论。
