[内源性竞争RNA的研究进展]
[Research progress of competing endogenous RNA].
作者信息
Wang Lin, Liu Jie
机构信息
The 2nd clinical college of China Medical University, Shenyang 110013, P.R.China.
The Science Experiment Center of China Medical University, Shenyang 110122, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Dec 1;34(6):967-971. doi: 10.7507/1001-5515.201606080.
Abstract
The competing endogenous RNA (ceRNA) hypothesis is a new pattern of gene posttranscriptional regulation. Encoding mRNA, long noncoding RNA (lncRNA), pseudogene transcript, circular RNA (circRNA), etc. can regulate gene expression by binding microRNA (miRNA). According to the research, ceRNA regulatory network participates in the maintenance of normal physiological state, occurrence and development of diseases. This paper reviewed ceRNA with the following respects: the proposal of ceRNA hypothesis, members of ceRNA regulatory network, research status, limitations and future development directions of this hypothesis. It will contribute to clarify the pathogenesis of much diseases including tumor and provide a new strategy for the diagnosis and treatment of disease.
摘要
竞争性内源性RNA（ceRNA）假说 是一种基因转录后调控的新模式。编码mRNA、长链非编码RNA（lncRNA）、假基因转录本、环状RNA（circRNA）等可通过结合微小RNA（miRNA）来调控基因表达。研究表明，ceRNA调控网络参与正常生理状态的维持以及疾病的发生发展。本文从ceRNA假说的提出、ceRNA调控网络的成员、该假说的研究现状、局限性及未来发展方向等方面进行综述。这将有助于阐明包括肿瘤在内的多种疾病的发病机制，并为疾病的诊断和治疗提供新策略。
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