Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Munich, Germany.
Ann N Y Acad Sci. 2019 Jan;1435(1):57-78. doi: 10.1111/nyas.13739. Epub 2018 May 15.
Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resistant fungal pathogens, including several Candida and Cryptococcus species, as well as mold pathogens. As these new and increasingly drug-resistant fungal pathogens continue to emerge, novel strategies for rapid identification and treatment are necessary to combat these life-threatening infections.
真菌病原体对公共健康构成日益严重的威胁。随着人类免疫缺陷的日益普遍，真菌感染也越来越普遍。抗真菌药物的使用，用于预防和治疗真菌感染，有利于以前罕见或未识别的耐药真菌病原体的出现，包括几种念珠菌和隐球菌物种，以及霉菌病原体。随着这些新的、越来越耐药的真菌病原体不断出现，有必要采取新的快速鉴定和治疗策略来对抗这些危及生命的感染。
