Karjigi S, Murthy S C, Kallappa H, Kusuma M R, Aruna B, Reddy Y N
Indian J Lepr. 2016 Sep;87(4):233-239.
Dapsone is an extensively Used drug for the treatment of leprosy as well as'some other clinical problems worldwide: Its use has been predicted to increase further, especially in non leprosy conditions. Treatment with Dapsone is sometimes known'to be associated with side-effects, which include gastrointestinal intolerance, haemolysis, methaemoglobinaemia, agranulocytosis, psychosis, peripheral neuritis and varied dermatological conditions, varying from simple rash to severe life threatening epidermolytic reactions and Dapsone hypersensitivity syndrome (DHS). DHS is a rare delayed hypersensitivity reaction involving multiple organs. the condition is associated with high morbidity and is potentially fatal. In this article, the focus is on etiopathogenesis, diagnosis and management of DHS. Awareness of the varied presentation/s of the condition, early recognition, withdrawal of the drug and proper management helps in rapid reduction in morbidity and preventing fatalities associated with it.
氨苯砜是一种在全球广泛用于治疗麻风病以及其他一些临床问题的药物。预计其使用量还会进一步增加，尤其是在非麻风病的病症中。有时已知使用氨苯砜会伴有副作用，包括胃肠道不耐受、溶血、高铁血红蛋白血症、粒细胞缺乏症、精神病、周围神经炎以及各种皮肤病，从简单的皮疹到严重的危及生命的表皮松解反应和氨苯砜超敏综合征（DHS）不等。DHS是一种涉及多个器官的罕见迟发型超敏反应。这种病症发病率高且有潜在致命性。本文重点关注DHS的病因发病机制、诊断和管理。了解该病症的多种表现形式、早期识别、停药及妥善管理有助于迅速降低发病率并预防与之相关的死亡。
