1 Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
2 Department of Otolaryngology-Head and Neck Surgery, King Saud University, Riyadh, Saudi Arabia.
Otolaryngol Head Neck Surg. 2018 Sep;159(3):587-589. doi: 10.1177/0194599818776640. Epub 2018 May 15.
Inverted papillomas are tumors of the sinonasal tract with a propensity to recur. Raman spectroscopy can potentially identify inverted papillomas from other tissue based on biochemical signatures. A pilot study comparing Raman spectroscopy to histopathology for 3 types of sinonasal tissue was performed. Spectral data of biopsies from patients with normal sinonasal mucosa, chronic rhinosinusitis, and inverted papillomas are compared to histopathology using principal component analysis and linear discriminant analysis after data preprocessing. A total of 18 normal, 15 chronic rhinosinusitis, and 18 inverted papilloma specimens were evaluated. The model distinguished normal sinonasal mucosa, chronic rhinosinusitis, and inverted papilloma tissue with an overall accuracy of 90.2% (95% confidence interval, 0.86-0.94). In conclusion, Raman spectroscopy can distinguish inverted papilloma, normal sinonasal mucosa, and chronically rhinosinusitis tissue with acceptable accuracy.
内翻性乳头状瘤是一种易复发的鼻窦道肿瘤。拉曼光谱技术可能基于生物化学特征，从其他组织中识别内翻性乳头状瘤。对 3 种鼻窦组织进行了拉曼光谱与组织病理学的对比研究。对来自正常鼻窦黏膜、慢性鼻-鼻窦炎和内翻性乳头状瘤患者的活检标本进行光谱数据分析，通过主成分分析和线性判别分析，对数据预处理后与组织病理学进行比较。共评估了 18 例正常鼻窦黏膜、15 例慢性鼻-鼻窦炎和 18 例内翻性乳头状瘤标本。该模型可准确地区分正常鼻窦黏膜、慢性鼻-鼻窦炎和内翻性乳头状瘤组织，总体准确率为 90.2%（95%置信区间，0.86-0.94）。总之，拉曼光谱技术可以以可接受的准确度区分内翻性乳头状瘤、正常鼻窦黏膜和慢性鼻-鼻窦炎组织。
