Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Department of Otolaryngology-Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao, China.
Acta Otolaryngol. 2021 May;141(5):513-518. doi: 10.1080/00016489.2021.1890819. Epub 2021 Apr 1.
Storz Professional Image Enhancement System (SPIES) endoscopy is an optical method to enhance the visualization of microvasculature on the mucosal surface and characterize epithelial changes.
In this study, we aimed to detect sinonasal inverted papilloma (SIP) in the microvasculature and/or mucosa using SPIES endoscopy.
A total of 115 subjects, including 80 patients with SIPs or nasal polyps (NPs) and 35 healthy controls were investigated using white light endoscopy (WLE) and SPIES endoscopy. All lesions were diagnosed by histopathological examination. We used Kappa index () to evaluate the agreement of WLE and SPIES endoscopy with the histopathology. The sensitivity, specificity, positive predictive value, and negative predictive value were independently determined.
NPs were histologically confirmed in 44 subjects (55%, 44/80), identified by WLE in 41 subjects (51.3%, 41/80), and identified by SPIES endoscopy in 43 subjects (53.8%, 43/80). SIPs were histologically confirmed in 36 cases (45%, 36/80), defined by WLE in 24 cases (30%, 24/80), and identified by SPIES endoscopy in 33 cases (41.3%, 33/80). Among 36 SIP patients, 33 cases (91.67%, 33/36) had a small lobular sign. The diagnosis of SIP by SPIES endoscopy was in excellent agreement with histopathological diagnosis ( = 0.873), while the diagnosis of SIP by WLE was in moderate agreement ( = 0.563).
SPIES endoscopy is a rapid and noninvasive live-imaging technique with a unique contrast to examine sinonasal mucosa, submucosa and microvasculature. Our study suggested SPIES endoscopy could detect SIP, and the small lobular sign could be a sensitive predictor of SIP diagnosis.
STORZ 专业图像增强系统 (SPIES) 内镜是一种光学方法，可增强黏膜表面微血管的可视化程度，并对上皮变化进行特征描述。
本研究旨在通过 SPIES 内镜检测鼻窦内翻性乳头状瘤 (SIP) 的微血管和/或黏膜。
共纳入 115 名受试者，包括 80 名 SIP 或鼻息肉 (NP) 患者和 35 名健康对照者，分别采用白光内镜 (WLE) 和 SPIES 内镜进行检查。所有病变均经组织病理学检查确诊。采用 Kappa 指数 () 评估 WLE 和 SPIES 内镜与组织病理学的一致性。独立确定了敏感性、特异性、阳性预测值和阴性预测值。
44 名受试者 (55%，44/80) 的 NP 经组织学证实，41 名受试者 (51.3%，41/80) 经 WLE 发现，43 名受试者 (53.8%，43/80) 经 SPIES 内镜发现。36 名 SIP 患者经组织学证实 (45%，36/80)，24 名患者 (30%，24/80) 经 WLE 发现，33 名患者 (41.3%，33/80) 经 SPIES 内镜发现。36 例 SIP 患者中，33 例 (91.67%，33/36) 存在小结节样改变。SPIES 内镜诊断 SIP 与组织病理学诊断具有极好的一致性 ( = 0.873)，而 WLE 诊断 SIP 的一致性为中度 ( = 0.563)。
SPIES 内镜是一种快速、非侵入性的实时成像技术，具有独特的对比度，可用于检查鼻-鼻窦黏膜、黏膜下组织和微血管。本研究提示 SPIES 内镜可检测 SIP，小结节样改变可能是 SIP 诊断的敏感预测指标。
