Alamoudi Najlaa M, Almabadi Eman S, El Ashiry Eman A, El Derwi Douaa A
J Clin Pediatr Dent. 2018;42(5):331-338. doi: 10.17796/1053-4625-42.5.2. Epub 2018 May 15.
To evaluate the effect of probiotic Lactobacilli reuteri lozenges on caries-associated salivary bacterial counts (Mutans streptococci and Lactobacillus), dental plaque accumulation, and salivary buffer capacity in a group of preschool children.
The study group consisted of 178 healthy children (aged 3-6 years). Children were randomly grouped: the experimental group (n = 90) received L. reuteri probiotic lozenges and the control group (n = 88) received placebo lozenges, twice daily, for 28 days. Salivary Mutans streptococci and Lactobacillus counts, and buffer capacity were assessed using chair-side caries-risk test (CRT®) kits. The Simplified Oral Hygiene index (OHI-S) was used to assess dental plaque accumulation at baseline and after 28 days.
After 28 days, the experimental group had a statistically significant reduction in Mutans streptococci and lactobacilli (p = 0.000 and p = 0.020, respectively) and both groups had less plaque accumulation than at baseline. While the buffer capacity in the experimental group increased more than in the control group, it was not statistically significant (p = 0.577). Compliance was 90%, with no adverse events.
Consumption of probiotic lozenges containing L. reuteri reduces caries-associated bacterial counts significantly. Probiotics consumption may have a beneficial caries-preventive effect.
评估益生菌罗伊氏乳杆菌含片对一组学龄前儿童龋齿相关唾液细菌计数（变形链球菌和乳酸菌）、牙菌斑积聚及唾液缓冲能力的影响。
研究组由178名健康儿童（3至6岁）组成。儿童被随机分组：实验组（n = 90）接受罗伊氏乳杆菌益生菌含片，对照组（n = 88）接受安慰剂含片，每日两次，共28天。使用椅旁龋齿风险测试（CRT®）试剂盒评估唾液中变形链球菌和乳酸菌计数以及缓冲能力。简化口腔卫生指数（OHI-S）用于评估基线及28天后的牙菌斑积聚情况。
28天后，实验组的变形链球菌和乳酸菌数量有统计学显著减少（分别为p = 0.000和p = 0.020），且两组的牙菌斑积聚均少于基线时。虽然实验组的缓冲能力增加幅度大于对照组，但差异无统计学意义（p = 0.577）。依从性为90%，无不良事件发生。
食用含罗伊氏乳杆菌的益生菌含片可显著降低龋齿相关细菌计数。食用益生菌可能具有有益的防龋效果。
