Dental Department, Universitas Indonesia Hospital, Universitas Indonesia, Depok, West Java, 16424, Indonesia.
Department of Oral Biology, Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia.
F1000Res. 2024 Mar 4;12:1495. doi: 10.12688/f1000research.139697.1. eCollection 2023.
Dysbiosis among oral microbial community in the oral cavity can lead to several oral diseases. Probiotic therapy is known to correct these imbalances. is one of the most studied strains of probiotics and can control oral microbiota through reuterin, a wide-spectrum antimicrobial agent. The objective of this review was to evaluate the effect of the antimicrobial activity of on the oral bacteria of humans. This review used PubMed, Scopus, EMBASE, ScienceDirect, and Google Scholar databases as bibliographic resources. Studies with matching keywords were analyzed and screened with PRISMA-ScR recommendations. Sixteen articles were selected for this review, which included a total of 832 patients. Based on this review, has a strong antibacterial effect against in healthy individuals but is not effective against Additionally, it has a significant antibacterial effect against in patients with periodontitis, although its effectiveness is not stable in patients with peri-implant infections. Furthermore, has varying results against other bacteria, indicating the need for further extensive research to ensure its efficacy.
口腔微生物群落失调会导致多种口腔疾病。已知益生菌疗法可以纠正这些失衡。 是研究最多的益生菌菌株之一,它可以通过一种广谱抗菌剂——瑞特菌素来控制口腔微生物群。本综述的目的是评估 对人类口腔细菌的抗菌活性的影响。本综述使用了 PubMed、Scopus、EMBASE、ScienceDirect 和 Google Scholar 数据库作为文献资源。根据 PRISMA-ScR 建议对具有匹配关键字的研究进行了分析和筛选。有 16 篇文章被选入本综述,其中总共包括 832 名患者。根据本综述, 在健康个体中对 具有很强的抗菌作用,但对 无效。此外,它对牙周炎患者的 具有显著的抗菌作用,尽管在种植体周围感染患者中的效果不稳定。此外, 对其他细菌的结果不同,这表明需要进一步进行广泛的研究以确保其疗效。