Peng D, Wang S P, Zhao D H, Fan Q C, Shu J, Liu J H
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Zhonghua Yi Xue Za Zhi. 2018 May 8;98(17):1337-1341. doi: 10.3760/cma.j.issn.0376-2491.2018.17.011.
To explore the effect of hyperuricemia on prognosis in patients with heart failure of coronary heart disease (CHD) after revascularization. A single-center retrospective study of all subjects who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) as revascularization for CHD at Beijing Anzhen Hospital, Capital Medical University, between January 2005 and December 2014 was performed.Patients were divided into two groups by with or without hyperuricemia.The average follow-up was 1 818 d. The Logistic regression analysis revealed that hyperuricemia was independent risk factors of readmission of heart failure(=0.018, =1.499, 95% 1.071-2.098). The Cox regression analysis revealed that hyperuricemia was independent risk factor of all-cause mortality(=0.002, =1.520, 95% 1.166-1.982), cardiovascular () mortality(=0.001, =1.811, 95% 1.279-2.566), heart failure mortality(=0.006, =2.151, 95% 1.247-3.711). There is negative correlation between level of uric acid and left ventricular ejection fraction (LVEF). The patients with heart failure of coronary heart disease complicated with hyperuricemia have high risk of readmission of heart failure, all-cause mortality, mortality andheart failure mortality than patients with normal uric acid level. Hyperuricemia is an independent risk factor for patients with heart failure of coronary heart disease after revascularization.
探讨高尿酸血症对冠心病(CHD)心力衰竭患者血运重建术后预后的影响。对2005年1月至2014年12月期间在首都医科大学附属北京安贞医院因CHD接受经皮冠状动脉介入治疗(PCI)或冠状动脉旁路移植术(CABG)进行血运重建的所有受试者进行了一项单中心回顾性研究。患者按有无高尿酸血症分为两组。平均随访时间为1818天。Logistic回归分析显示,高尿酸血症是心力衰竭再入院的独立危险因素(P = 0.018,OR = 1.499,95%CI 1.071 - 2.098)。Cox回归分析显示,高尿酸血症是全因死亡(P = 0.002,HR = 1.520,95%CI 1.166 - 1.982)、心血管(CV)死亡(P = 0.001,HR = 1.811,95%CI 1.279 - 2.566)、心力衰竭死亡(P = 0.006,HR = 2.15l,95%CI 1.247 - 3.711)的独立危险因素。尿酸水平与左心室射血分数(LVEF)呈负相关。与尿酸水平正常的患者相比,冠心病心力衰竭合并高尿酸血症的患者心力衰竭再入院、全因死亡、CV死亡和心力衰竭死亡风险更高。高尿酸血症是冠心病心力衰竭患者血运重建术后的独立危险因素。