Cosmetic Plastic Surgery Center, Beirut, Lebanon.
Stem Cells, Organogenesis and and Regenerative Medicine, Lebanese University, Beirut, Lebanon.
Stem Cell Res Ther. 2018 May 15;9(1):141. doi: 10.1186/s13287-018-0889-y.
Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. The potential use of stem cell-based therapies (SCBT) for the repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions, which can be applied to prevent hair loss. This study aimed to present clinical cases of SCBT for the treatment of alopecia areata by transplantation of ADSVCs in the scalp.
Twenty patients (9 women and 11 men) were recruited to our retrospectively registered study. After lipoaspiration, autologous ADSVCs were generated and characterized before the injection of 4-4.7 × 10 cells into the scalp of the patient. Hair regeneration was assessed by three clinical tests: the pull test, hair quality, and hair density.
All patients experienced hair regeneration, increased hair growth and decreased pull test 3 and 6 months after the treatment with ADSVCs [hair density (85.1 ± 8.7 vs 121.1 ± 12.5 hair/cm, P < 0.0001), hair diameter (60.5 ± 1.8 vs 80.8 ± 2.4μ, P < 0.0001) and pull-test values (4.4 ± 0.3 vs 0.8 ± 0.2, P < 0.0001), untreated versus 6 months post-operative)]. Significant variation was observed between men and women only for hair diameter. No significant differences were observed with age.
The obtained results prove the efficacy and the safety of the treatment, and satisfaction of the patients confirm the quality of the results.
大多数常见的脱发形式（脱发症）是由于毛囊周期异常和毛囊形态变化引起的。然而，目前针对脱发症的治疗方法并不能针对这些过程。脂肪来源的基质血管细胞（ADSVCS）可以从脂肪细胞中提取，是美容领域的最新突破之一。基于干细胞的治疗（SCBT）在修复和再生各种组织和器官方面的潜在应用提供了一种范式转变，可能提供替代的治疗解决方案，可应用于预防脱发。本研究旨在通过头皮注射 ADSVCs 来介绍治疗斑秃的 SCBT 的临床病例。
我们回顾性注册了 20 名患者（9 名女性和 11 名男性）参与本研究。脂肪抽吸后，生成并鉴定自体 ADSVCs，然后将 4-4.7×10个细胞注射到患者头皮中。通过三种临床测试评估头发再生：拔毛试验、头发质量和头发密度。
所有患者在接受 ADSVCs 治疗 3 和 6 个月后均经历了头发再生、毛发生长增加和拔毛试验值降低[头发密度（85.1±8.7 比 121.1±12.5 根/cm，P<0.0001）、头发直径（60.5±1.8 比 80.8±2.4μm，P<0.0001）和拔毛试验值（4.4±0.3 比 0.8±0.2，P<0.0001），未治疗与术后 6 个月]。仅在男性和女性之间观察到头发直径存在显著差异。年龄无显著差异。
所得结果证明了该治疗方法的疗效和安全性，患者的满意度证实了结果的质量。
