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使用脂肪来源干细胞条件培养基的毛发再生治疗：毛发显微镜检查随访

Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms.

作者信息

Fukuoka Hirotaro, Suga Hirotaka

机构信息

Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and Reconstructive Surgery, Kyorin University, Tokyo, Japan.

出版信息

Eplasty. 2015 Mar 26;15:e10. eCollection 2015.

PMID:25834689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4379938/
Abstract

OBJECTIVE

Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia.

METHODS

Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women).

RESULTS

Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.

CONCLUSION

Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

摘要

目的

脂肪来源干细胞分泌多种促进头发生长的生长因子。本研究检测了脂肪来源干细胞条件培养基对脱发的影响。

方法

对22例（11例男性和11例女性）脱发患者进行脂肪来源干细胞条件培养基皮内注射。患者每3至5周接受一次治疗，共6次。治疗前后使用毛发计数图计算毛发数量。还对10例患者（8例男性和2例女性）进行了半侧对照研究。

结果

男性（包括未服用非那雄胺的患者）和女性患者治疗后毛发数量均显著增加。在半侧对照研究中，治疗侧毛发数量的增加显著高于安慰剂侧。

结论

使用脂肪来源干细胞条件培养基治疗脱发似乎非常有效，可能代表一种新的毛发再生疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/60e9a7b83d8e/eplasty15e10_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/d6aea84c3ec9/eplasty15e10_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/8e2e9270dff0/eplasty15e10_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/aa88a13077cc/eplasty15e10_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/21353e3f4089/eplasty15e10_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/6cce3559243b/eplasty15e10_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/2229c7285f0f/eplasty15e10_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/60e9a7b83d8e/eplasty15e10_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/d6aea84c3ec9/eplasty15e10_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/8e2e9270dff0/eplasty15e10_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/aa88a13077cc/eplasty15e10_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/21353e3f4089/eplasty15e10_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/6cce3559243b/eplasty15e10_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/2229c7285f0f/eplasty15e10_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f24/4379938/60e9a7b83d8e/eplasty15e10_fig7.jpg

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Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling.脂肪细胞谱系细胞有助于皮肤干细胞龛，以驱动毛发周期。
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Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion.
人骨髓间充质干细胞条件培养基多次全身给药用于多种慢性疾病的安全性评估。
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Molecular Mechanisms of Hair Follicle Development.毛囊发育的分子机制
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