1Department of Pharmacology and Therapeutics,State University of Maringá,Maringá,Paraná,Brazil.
2Department of Physiological Sciences,Federal University of Santa Catarina,Florianópolis,Santa Catarina,Brazil.
Acta Neuropsychiatr. 2019 Feb;31(1):1-16. doi: 10.1017/neu.2018.11. Epub 2018 May 16.
Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline. Qualitative evaluation of the selected studies indicated that activation of cannabinoid receptors may change neurogenesis in embryonic or adult nervous systems alongside rescue of phenotypes in animal models of different psychiatric and neurological disorders. The text offers an overview on the effects of cannabinoids on central nervous system development and the possible links with psychiatric and neurological disorders such as anxiety, depression, schizophrenia, brain ischaemia/stroke and Alzheimer's disease. An understanding of the mechanisms by which cannabinoid signalling influences developmental and adult neurogenesis will help foster the development of new therapeutic strategies for neurodevelopmental, psychiatric and neurological disorders.
大麻素信号调节大脑功能的多个方面，包括胚胎期和成年期神经元的产生和存活。本综述旨在总结支持内源性大麻素系统在控制神经发生和神经发生依赖功能中的作用的证据。从 Medline 中选择了报道大麻素参与调节神经发生的任何步骤以及大麻素化合物对具有神经发生依赖特征的动物模型的影响的研究。对所选研究的定性评估表明，大麻素受体的激活可能会改变胚胎或成年神经系统中的神经发生，同时挽救不同精神和神经障碍动物模型的表型。本文概述了大麻素对中枢神经系统发育的影响，以及与焦虑、抑郁、精神分裂症、脑缺血/中风和阿尔茨海默病等精神和神经障碍的可能联系。了解大麻素信号影响发育和成年神经发生的机制将有助于为神经发育、精神和神经障碍开发新的治疗策略。
